Genetics and biology of pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death in the
United States with a median survival of< 6 mo and a dismal 5-yr survival rate of 3%–5%. The …
United States with a median survival of< 6 mo and a dismal 5-yr survival rate of 3%–5%. The …
The role of stroma in pancreatic cancer: diagnostic and therapeutic implications
Pancreatic ductal adenocarcinoma (PDAC) is one of the five most lethal malignancies
worldwide and survival has not improved substantially in the past 30 years. Desmoplasia …
worldwide and survival has not improved substantially in the past 30 years. Desmoplasia …
Extracellular vesicle and particle biomarkers define multiple human cancers
There is an unmet clinical need for improved tissue and liquid biopsy tools for cancer
detection. We investigated the proteomic profile of extracellular vesicles and particles …
detection. We investigated the proteomic profile of extracellular vesicles and particles …
[HTML][HTML] Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis
SA Melo, H Sugimoto, JT O'Connell, N Kato… - Cancer cell, 2014 - cell.com
Exosomes are secreted by all cell types and contain proteins and nucleic acids. Here, we
report that breast cancer associated exosomes contain microRNAs (miRNAs) associated …
report that breast cancer associated exosomes contain microRNAs (miRNAs) associated …
YAP1 increases organ size and expands undifferentiated progenitor cells
The mechanisms that regulate mammalian organ size are poorly understood. It is unclear
whether the pathways that control organ size also im**e on stem/progenitor cells. A highly …
whether the pathways that control organ size also im**e on stem/progenitor cells. A highly …
Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice
Pancreatic ductal adenocarcinoma (PDA), one of the deadliest human cancers, often
involves somatic activation of K-Ras oncogenes. We report that selective expression of an …
involves somatic activation of K-Ras oncogenes. We report that selective expression of an …
Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma
Tumors are largely classified by histologic appearance, yet morphologic features do not
necessarily predict cellular origin. To determine the origin of pancreatic ductal …
necessarily predict cellular origin. To determine the origin of pancreatic ductal …
Pancreatic cancer
The past two decades have witnessed an explosion in our understanding of pancreatic
cancer, and it is now clear that pancreatic cancer is a disease of inherited (germ-line) and …
cancer, and it is now clear that pancreatic cancer is a disease of inherited (germ-line) and …
PTEN loss in the continuum of common cancers, rare syndromes and mouse models
MC Hollander, GM Blumenthal, PA Dennis - Nature Reviews Cancer, 2011 - nature.com
PTEN is among the most frequently inactivated tumour suppressor genes in sporadic
cancer. PTEN has dual protein and lipid phosphatase activity, and its tumour suppressor …
cancer. PTEN has dual protein and lipid phosphatase activity, and its tumour suppressor …
Pancreas organogenesis: from bud to plexus to gland
FC Pan, C Wright - Developmental dynamics, 2011 - Wiley Online Library
Pancreas oganogenesis comprises a coordinated and highly complex interplay of signaling
events and transcriptional networks that guide a step‐wise process of organ development …
events and transcriptional networks that guide a step‐wise process of organ development …