The evolution of AMPK and its homologs enabled exquisite responsivity and control of
cellular energetic homeostasis. Recent work has been critical in establishing the …

Adaptive immunity is essential for pathogen and tumor eradication, but may also trigger
uncontrolled or pathological inflammation. T cell receptor, co-stimulatory and cytokine …

Colorectal cancer (CRC) accounts for over 8% of all deaths annually worldwide. Between 2
and 5% of all CRCs occur due to inherited syndromes, including Lynch syndrome, familial …

The mammalian target of rapamycin (mTOR) is a central controller of cell growth and
proliferation. mTOR forms two distinct complexes, mTOR complex 1 (mTORC1) and mTOR …

The AMP-activated protein kinase (AMPK) is an evolutionarily conserved sensor of cellular
energy status, and recent data demonstrate that it also plays a critical role in systemic …

We recently demonstrated that the LKB1 tumour suppressor kinase, in complex with the
pseudokinase STRAD and the scaffolding protein MO25, phosphorylates and activates AMP …

The prevalence of obesity has been steadily increasing over the past few decades in several
developed and develo** countries, with resultant hazardous health implications …

The oxidative pentose phosphate pathway (PPP) contributes to tumour growth, but the
precise contribution of 6-phosphogluconate dehydrogenase (6PGD), the third enzyme in this …

The AMP-activated protein kinase (AMPK) cascade is a sensor of cellular energy status.
Whenever the cellular ATP: ADP ratio falls, owing to a stress that inhibits ATP production or …

SIRT1, a histone/protein deacetylase, and AMP-activated protein kinase (AMPK) are key
enzymes responsible for longevity and energy homeostasis. We examined whether a …