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[HTML][HTML] Intrinsically disordered proteins: an overview
Many proteins and protein segments cannot attain a single stable three-dimensional
structure under physiological conditions; instead, they adopt multiple interconverting …
structure under physiological conditions; instead, they adopt multiple interconverting …
Introducing protein intrinsic disorder
Proteins are the major component of the living cell. They play crucial roles in the
maintenance of life, and their dysfunctions are known to cause different pathologies. One of …
maintenance of life, and their dysfunctions are known to cause different pathologies. One of …
Omicron and Delta variant of SARS‐CoV‐2: a comparative computational study of spike protein
Emerging severe acute respiratory syndrome coronavirus type 2 (SARS‐CoV‐2) variants,
especially those of concern, may have an impact on the virus's transmissibility and …
especially those of concern, may have an impact on the virus's transmissibility and …
Intermolecular interactions underlie protein/peptide phase separation irrespective of sequence and structure at crowded milieu
Liquid-liquid phase separation (LLPS) has emerged as a crucial biological phenomenon
underlying the sequestration of macromolecules (such as proteins and nucleic acids) into …
underlying the sequestration of macromolecules (such as proteins and nucleic acids) into …
Rapid prediction and analysis of protein intrinsic disorder
Protein intrinsic disorder is found in all kingdoms of life and is known to underpin numerous
physiological and pathological processes. Computational methods play an important role in …
physiological and pathological processes. Computational methods play an important role in …
A prion-like protein regulator of seed germination undergoes hydration-dependent phase separation
Many organisms evolved strategies to survive desiccation. Plant seeds protect dehydrated
embryos from various stressors and can lay dormant for millennia. Hydration is the key …
embryos from various stressors and can lay dormant for millennia. Hydration is the key …
Metapredict: a fast, accurate, and easy-to-use predictor of consensus disorder and structure
Intrinsically disordered proteins and protein regions make up a substantial fraction of many
proteomes in which they play a wide variety of essential roles. A critical first step in …
proteomes in which they play a wide variety of essential roles. A critical first step in …
Phase separation properties of RPA combine high-affinity ssDNA binding with dynamic condensate functions at telomeres
RPA has been shown to protect single-stranded DNA (ssDNA) intermediates from instability
and breakage. RPA binds ssDNA with sub-nanomolar affinity, yet dynamic turnover is …
and breakage. RPA binds ssDNA with sub-nanomolar affinity, yet dynamic turnover is …
The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics
P granules and other RNA/protein bodies are membrane-less organelles that may assemble
by intracellular phase separation, similar to the condensation of water vapor into droplets …
by intracellular phase separation, similar to the condensation of water vapor into droplets …
Ubiquitin modulates liquid-liquid phase separation of UBQLN2 via disruption of multivalent interactions
Under stress, certain eukaryotic proteins and RNA assemble to form membraneless
organelles known as stress granules. The most well-studied stress granule components are …
organelles known as stress granules. The most well-studied stress granule components are …