SUMMARY ATP-binding cassette (ABC) systems are universally distributed among living
organisms and function in many different aspects of bacterial physiology. ABC transporters …

The acquisition of multidrug resistance is a serious impediment to improved healthcare.
Multidrug resistance is most frequently due to active transporters that pump a broad …

Lipopolysaccharide (LPS) in the outer membrane of Gram-negative bacteria is critical for the
assembly of their cell envelopes. LPS synthesized in the cytoplasmic leaflet of the inner …

P-glycoprotein (P-gp) detoxifies cells by exporting hundreds of chemically unrelated toxins
but has been implicated in multidrug resistance (MDR) in the treatment of cancers. Substrate …

Molecular dynamics simulations of membrane proteins have provided deeper insights into
their functions and interactions with surrounding environments at the atomic level. However …

Over 1 million new cases of all types of cancer are diagnosed each year in the United States
alone, and 559 650 cancer-related deaths were expected to occur in 2007. 1 …

ATP-binding cassette (ABC) transporters are integral membrane proteins that translocate a
wide variety of substrates across cellular membranes and are conserved from bacteria to …

Trap** membrane proteins in the confines of a crystal lattice obscures dynamic modes
essential for interconversion between multiple conformations in the functional cycle …

Site-directed spin labeling has become a popular biophysical tool for the characterization of
protein structure, dynamics and conformational change. This method is well suited and …

ATP-binding cassette (ABC) transporters utilize the energy from ATP hydrolysis to transport
substances across the membrane. In recent years, crystal structures of several ABC …