Abstract FACT (FAcilitates Chromatin Transcription) has long been considered to be a
transcription elongation factor whose ability to destabilize nucleosomes promotes RNAPII …

In eukaryotic cells, transcription by RNA polymerase II occurs in the context of chromatin,
requiring the transcription machinery to navigate through nucleosomes as it traverses gene …

Facilitates chromatin transcription (FACT) is a histone chaperone that supports transcription
through chromatin in vitro, but its functional roles in vivo remain unclear. Here, we analyze …

The cohesin complex topologically encircles DNA to promote sister chromatid cohesion.
Alternatively, cohesin extrudes DNA loops, thought to reflect chromatin domain formation …

Chromatin remodelers are ATP-dependent enzymes that reorganize nucleosomes within all
eukaryotic genomes. Here we report a complex of the Chd1 remodeler bound to a …

The histone chaperone FACT occupies transcribed regions where it plays prominent roles in
maintaining chromatin integrity and preserving epigenetic information. How it is targeted to …

In eukaryotes, genomic DNA is tightly wrapped in chromatin. The nucleosome is a basic unit
of chromatin, but acts as a barrier to transcription. To overcome this impediment, the RNA …

The identification of FACT as a histone chaperone enabling transcription through chromatin
in vitro has strongly shaped how its roles are envisioned. However, FACT has been …

The heterodimeric histone chaperone FACT, consisting of SSRP1 and SPT16, contributes to
dynamic nucleosome rearrangements during various DNA-dependent processes including …

FACT is a histone chaperone that participates in nucleosome removal and reassembly
during transcription and replication. We used electron microscopy to study FACT, FACT …