Understudied factors in drug‐coated balloon design and evaluation: A biophysical perspective

T Shazly, WM Torres, EA Secemsky… - Bioengineering & …, 2023 - Wiley Online Library
Drug‐coated balloon (DCB) percutaneous interventional therapy allows for durable
reopening of the narrowed lumen via physical tissue expansion and local anti‐restenosis …

[HTML][HTML] Mathematical modelling of endovascular drug delivery: Balloons versus stents

J Escuer, AF Schmidt, E Pena, MA Martínez… - International Journal of …, 2022 - Elsevier
The most common treatment for obstructive coronary artery disease (CAD) is the
implantation of a permanent drug-eluting stent (DES). Not only has this permanency been …

Plaque heterogeneity and the spatial distributions of its components dictate drug-coated balloon therapy

Sarifuddin, PK Mandal - Scientific Reports, 2024 - nature.com
Drug-coated balloon (DCB) angioplasty is one of the potential approaches to alleviating in-
stent restenosis and treating peripheral artery disease. An in-silico model has been …

[HTML][HTML] An intricate interplay between stent drug dose and release rate dictates arterial restenosis

A McQueen, J Escuer, AF Schmidt, A Aggarwal… - Journal of Controlled …, 2022 - Elsevier
Since the introduction of percutaneous coronary intervention (PCI) for the treatment of
obstructive coronary artery disease (CAD), patient outcomes have progressively improved …

[HTML][HTML] Cardiovascular tissue engineering models for atherosclerosis treatment development

L Tscheuschner, AR Tzafriri - Bioengineering, 2023 - mdpi.com
In the early years of tissue engineering, scientists focused on the generation of healthy-like
tissues and organs to replace diseased tissue areas with the aim of filling the gap between …

Theoretical modeling of endovascular drug delivery into a multilayer arterial wall from a drug-coated balloon

A Jain, S McGinty, G Pontrelli, L Zhou - … Journal of Heat and Mass Transfer, 2022 - Elsevier
Drug-coated balloons (DCBs) are used commonly for delivering drug into diseased arteries.
When applied on the inner surface of an artery, drug is transported from the balloon into the …

Unsteady transport and two-phase binding of a drug in an atherosclerotic artery

S Biswas, S Sarifuddin, PK Mandal - Physics of Fluids, 2022 - pubs.aip.org
To quantify the biology and physical understanding of endovascular drug delivery, a
mathematical model that accounts for the two-phase binding of drug molecules in a …

[HTML][HTML] Plaque heterogeneity influences in-stent restenosis following drug-eluting stent implantation: Insights from patient-specific multiscale modelling

A Corti, L Dal Ferro, AC Akyildiz, F Migliavacca… - Journal of …, 2025 - Elsevier
In-stent restenosis represents a major cause of failure of percutaneous coronary intervention
with drug-eluting stent implantation. Computational multiscale models have recently …

Laplace Transform Based Modeling of Drug Delivery with Reversible Drug Binding in a Multilayer Tissue

A Jain, G Pontrelli, S McGinty - Pharmaceutical Research, 2024 - Springer
Objective Drug delivery from a drug-loaded device into an adjacent tissue is a complicated
process involving drug transport through diffusion and advection, coupled with drug binding …

[HTML][HTML] In Silico Investigation of the Interlaminar and Mechanical Fracture of Arteries with Atheromatic Plaque during Angioplasty Treatment

S Psarras, AN Skafidas, V Kostopoulos - Biomedicines, 2024 - pmc.ncbi.nlm.nih.gov
The reduction in the inner diameter of the artery due to the creation of atheromatic plaque on
the artery lumen, known as artery stenosis, disrupts the blood flow, leading to medical …