Biomedical applications of calixarenes: state of the art and perspectives

YC Pan, XY Hu, DS Guo - Angewandte Chemie International …, 2021 - Wiley Online Library
Calixarenes (CAs), representing the third generation of supramolecular hosts and one of the
most widely studied macrocyclic scaffolds, offer (almost) unlimited structure and application …

Molecular recognition with macrocyclic receptors for application in precision medicine

YC Pan, JH Tian, DS Guo - Accounts of Chemical Research, 2023 - ACS Publications
Conspectus Macrocyclic receptors can serve as alternatives to natural recognition systems
as recognition tools. They provide effectively preorganized cavities to encapsulate guests …

Drug in drug: a host–guest formulation of azocalixarene with hydroxychloroquine for synergistic anti‐inflammation

S Li, R Ma, XY Hu, HB Li, WC Geng, X Kong… - Advanced …, 2022 - Wiley Online Library
Macrocyclic delivery and therapeutics are two significant topics in supramolecular
biomedicine. The functional integration of these topics would open new avenues for treating …

A general hypoxia‐responsive molecular container for tumor‐targeted therapy

TX Zhang, ZZ Zhang, YX Yue, XY Hu… - Advanced …, 2020 - Wiley Online Library
Enhanced drug delivery can improve the therapeutic efficacy of drugs and help overcome
side effects. However, many reported drug‐delivery systems are too complex and …

Pillararene-based supramolecular systems for theranostics and bioapplications

H Zhu, Q Li, LE Khalil-Cruz, NM Khashab, G Yu… - Science China …, 2021 - Springer
As an emerging type of important macrocycles for supramolecular chemistry, pillararenes
and their derivatives have been widely studied and applied in numerous fields, which …

Supramolecular bioimaging through signal amplification by combining indicator displacement assay with Förster resonance energy transfer

WC Geng, Z Ye, Z Zheng, J Gao, JJ Li… - Angewandte …, 2021 - Wiley Online Library
Fluorescent chemosensors are powerful imaging tools in the fields of life sciences and
engineering. Based on the principle of supramolecular chemistry, indicator displacement …

Supramolecular radiosensitizer based on hypoxia‐responsive macrocycle

X Hou, YX Chang, YX Yue, ZH Wang, F Ding… - Advanced …, 2022 - Wiley Online Library
Radiotherapy (RT) has been viewed as one of the most effective and extensively applied
curatives in clinical cancer therapy. However, the radioresistance of tumor severely …

Assembling features of calixarene-based amphiphiles and supra-amphiphiles

HW Tian, YC Liu, DS Guo - Materials Chemistry Frontiers, 2020 - pubs.rsc.org
Macrocyclic amphiphiles as an emerging family of artificial amphiphiles have gained
considerable attention in recent years on account of their fascinating recognition and …

Cyclodextrin–phytochemical inclusion complexes: Promising food materials with targeted nutrition and functionality

Y Hu, C Qiu, Y Qin, X Xu, L Fan, J Wang… - Trends in Food Science & …, 2021 - Elsevier
Background Natural phytochemicals suffer from poor aqueous solubility and storage stability
as well as demonstrate limited bioaccessibility; thus, their effectiveness as food ingredients …

A host-guest drug delivery nanosystem for supramolecular chemotherapy

XY Hu, J Gao, FY Chen, DS Guo - Journal of Controlled Release, 2020 - Elsevier
Supramolecular chemotherapy is currently a new strategy to improve the therapeutic efficacy
as well as overcome the side effects of traditional chemotherapy. Herein, a supramolecular …