3D tumour models: novel in vitro approaches to cancer studies
Abstract 3D in vitro models have been used in cancer research as a compromise between 2-
dimensional cultures of isolated cancer cells and the manufactured complexity of xenografts …
dimensional cultures of isolated cancer cells and the manufactured complexity of xenografts …
Three-dimensional cell culture systems in radiopharmaceutical cancer research
Simple Summary Cancer cells cultured in three-dimensional (3D) model systems exhibit
physiologically relevant cell–cell and cell–matrix interactions, gene expression patterns, and …
physiologically relevant cell–cell and cell–matrix interactions, gene expression patterns, and …
Development of an in Vitro 3D Tumor Model to Study Therapeutic Efficiency of an Anticancer Drug
The importance and advantages of three-dimensional (3D) cell cultures have been well-
recognized. Tumor cells cultured in a 3D culture system as multicellular tumor spheroids …
recognized. Tumor cells cultured in a 3D culture system as multicellular tumor spheroids …
Rapid enhancement of cellular spheroid assembly by acoustically driven microcentrifugation
Intense acoustically driven microcentrifugation flows are employed to enhance the assembly
of cellular spheroids in the microwell of a tissue culture well plate. This ability to interface …
of cellular spheroids in the microwell of a tissue culture well plate. This ability to interface …
Development of radiotracers for oncology–the interface with pharmacology
R Sharma, E Aboagye - British journal of pharmacology, 2011 - Wiley Online Library
There is an increasing role for positron emission tomography (PET) in oncology, particularly
as a component of early phase clinical trials. As a non‐invasive functional imaging modality …
as a component of early phase clinical trials. As a non‐invasive functional imaging modality …
Uptake of 2-NBDG as a method to monitor therapy response in breast cancer cell lines
SR Millon, JH Ostrander, JQ Brown, A Raheja… - Breast cancer research …, 2011 - Springer
This study quantifies uptake of a fluorescent glucose analog,(2-(N-(7-nitrobenz-2-oxa-1, 3-
diazol-4-yl) amino)-2-deoxyglucose)(2-NBDG), in a large panel of breast cancer cells and …
diazol-4-yl) amino)-2-deoxyglucose)(2-NBDG), in a large panel of breast cancer cells and …
Multicellular tumor spheroids combined with mass spectrometric histone analysis to evaluate epigenetic drugs
PE Feist, S Sidoli, X Liu, MM Schroll, S Rahmy… - Analytical …, 2017 - ACS Publications
Multicellular tumor spheroids (MCTS) are valuable in vitro tumor models frequently used to
evaluate the penetration and efficacy of therapeutics. In this study, we evaluated potential …
evaluate the penetration and efficacy of therapeutics. In this study, we evaluated potential …
Application of the multicellular tumour spheroid model to screen PET tracers for analysis of early response of chemotherapy in breast cancer
A Monazzam, R Josephsson, C Blomqvist… - Breast Cancer …, 2007 - Springer
Introduction Positron emission tomography (PET) is suggested for early monitoring of
treatment response, assuming that effective anticancer treatment induces metabolic …
treatment response, assuming that effective anticancer treatment induces metabolic …
Multicellular spheroids as an in vitro model in experimental oncology: applications in translational medicine
D Khaitan, BS Dwarakanath - Expert opinion on drug discovery, 2006 - Taylor & Francis
Multicellular tumour spheroids (MCTS), the best-described three-dimensional tumour model,
offers an excellent in vitro screening system, which to a great extent mimics the …
offers an excellent in vitro screening system, which to a great extent mimics the …
3D tumour spheroids as a model to assess the suitability of [18F] FDG-PET as an early indicator of response to PI3K inhibition
CJ Kelly, K Hussien, RJ Muschel - Nuclear medicine and biology, 2012 - Elsevier
BACKGROUND:[18F] Fluorodeoxyglucose Positron Emission Tomography ([18F] FDG-PET)
is widely used to monitor response to therapy in the clinic and has, more recently, been …
is widely used to monitor response to therapy in the clinic and has, more recently, been …