Nanoparticles-based drug delivery and gene therapy for breast cancer: Recent advancements and future challenges

Z Mirza, S Karim - Seminars in cancer biology, 2021 - Elsevier
Breast cancer (BC) is amongst the most lethal cancer among females and conventional
treatment methods like surgery, radiotherapy and chemotherapy are not effective enough as …

Large-scale production of lentiviral vectors: current perspectives and challenges

E Martínez-Molina, C Chocarro-Wrona… - Pharmaceutics, 2020 - mdpi.com
Lentiviral vectors (LVs) have gained value over recent years as gene carriers in gene
therapy. These viral vectors are safer than what was previously being used for gene transfer …

[HTML][HTML] Silver Nanoparticles from Annona muricata Peel and Leaf Extracts as a Potential Potent, Biocompatible and Low Cost Antitumor Tool

MG González-Pedroza, L Argueta-Figueroa… - Nanomaterials, 2021 - mdpi.com
Cancer is one of the most prevalent diseases in the world and requires new therapies for its
treatment. In this context, the biosynthesis of silver nanoparticles (AgNPs) has been …

A Base‐Free Pd‐Precatalyst Mediated Suzuki‐Miyaura and Sonogashira Cross‐Coupling in Deep Eutectic Solvents

P Thiyagamurthy, FRN Khan - ChemistrySelect, 2020 - Wiley Online Library
A volatile organic solvent‐free deep eutectic solvent (DES) was prepared by utilizing 1: 10
ratio of potassium carbonate (PC) as a hydrogen bond acceptor (HBA) and ethylene glycol …

[HTML][HTML] Deciphering the mechanism of action involved in enhanced suicide gene colon cancer cell killer effect mediated by gef and apoptin

B Cáceres, A Ramirez, E Carrillo, G Jimenez… - Cancers, 2019 - mdpi.com
Despite the great advances in cancer treatment, colorectal cancer has emerged as the
second highest cause of death from cancer worldwide. For this type of tumor, the use of …

1, 5‐Benzoxazepines as a unique and potent scaffold for activity drugs: A review

M Stefaniak, B Olszewska - Archiv der Pharmazie, 2021 - Wiley Online Library
Benzoxazepines constitute a huge number of organic compounds widely described in the
literature. Many of them are distinguished by their biological properties. Among them, our …

[HTML][HTML] New substituted benzoxazine derivatives as potent inducers of membrane permeability and cell death

A Conejo-García, Y Jiménez-Martínez… - Bioorganic & Medicinal …, 2024 - Elsevier
The search for new agents targeting different forms of cell death is an important research
focus for develo** new and potent antitumor therapies. As a contribution to this endeavor …

Design, synthesis and in silico evaluation of benzoxazepino (7, 6-b) quinolines as potential antidiabetic agents

P Thiyagamurthy, C Teja, K Naresh, K Gomathi… - Medicinal Chemistry …, 2020 - Springer
The second-generation XPhos palladium preformed catalyst-based C–N cross-coupling
through Buchwald–Hartwig amination with primary and secondary amines towards …

[HTML][HTML] LdrB Toxin with In Vitro and In Vivo Antitumor Activity as a Potential Tool for Cancer Gene Therapy

Y Jiménez-Martínez, C Griñán-Lisón, H Khaldy… - Cancers, 2019 - mdpi.com
Due to the high prevalence of cancer in recent years, it is necessary to develop new and
more effective therapies that produce fewer side effects. Development of gene therapy for …

Emerging Therapeutic Approaches in Drug-Resistant Breast Cancer

T Molefi, T Chipiti, VP Belancio, Z Dlamini - Overcoming Breast Cancer …, 2024 - Springer
Breast cancer, a heterogeneous and complex disease, remains a significant healthcare
challenge around the world, with drug resistance being a major impediment to successful …