Study Design. A review is presented on current knowledge of the micromechanical factors in
the intervertebral disc, their role in modifying cell biology, and changes with degeneration …

Articular cartilage plays a vital role in the function of diarthrodial joints. Due to osteoarthritis
degeneration of articular cartilage occurs. The initial event that triggers the pathological …

The mechanical behavior of the entire anulus fibrosus is determined essentially by the
tensile properties of its lamellae, their fiber orientations, and the regional variation of these …

From a mechanical point of view, the most relevant components of articular cartilage are the
tight and highly organized collagen network together with the charged proteoglycans. Due to …

Chondrocytes in articular cartilage are regularly subjected to compression and recovery due
to dynamic loading of the joint. Previous studies have investigated the elastic and …

For this study, we hypothesized that the depth-dependent compressive equilibrium
properties of articular cartilage are the inherent consequence of its depth-dependent …

Study Design. Study of regional variations in composition in a sample of 9 mildly to
moderately degenerated human intervertebral discs. Objective. The aim of this study was to …

Study Design. Nondestructive displacement-controlled dynamic testing of cadaver material,
with repeated measures design and randomized sequence of tests. Objective. To determine …

This study pursues the numerical validation of human lumbar spine segments. By means of
the finite element (FE) method, computational analyses are carried out of various load …

Finite element models for hydrated soft biological tissue are numerous but often exhibit
certain essential deficiencies concerning the reproduction of relevant mechanical and …