Classically, polyunsaturated fatty acids (PUFA) were largely thought to be relatively inert
structural components of brain, largely important for the formation of cellular membranes …

The brain is highly enriched with fatty acids. These include the polyunsaturated fatty acids
(PUFAs) arachidonic acid and docosahexaenoic acid, which are largely esterified to the …

Depression is the leading cause of disability worldwide. Recent observations have revealed
an association between mood disorders and alterations of the intestinal microbiota. Here …

The golden age of cannabis pharmacology began in the 1960s as Raphael Mechoulam and
his colleagues in Israel isolated and synthesized cannabidiol, tetrahydrocannabinol, and …

Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is essential for normal brain
growth and cognitive function,,,. Consistent with its importance in the brain, DHA is highly …

Endocannabinoids are key modulators of synaptic function. By activating cannabinoid
receptors expressed in the central nervous system, these lipid messengers can regulate …

More than one-third of American adults are obese and statistics are similar worldwide.
Caloric intake and diet composition have large and lasting effects on cognition and emotion …

The blood–brain barrier (BBB) maintains the optimal microenvironment in the central
nervous system (CNS) for proper brain function. The BBB comprises specialized CNS …

Endocannabinoids and cannabinoid CB1 receptors are known to play a generalized role in
energy homeostasis. However, clinical trials with the first generation of CB1 blockers, now …

Despite being regarded as a hippie science for decades, cannabinoid research has finally
found its well-deserved position in mainstream neuroscience. A series of groundbreaking …