The metabolome, the collection of small-molecule chemical entities involved in metabolism,
has traditionally been studied with the aim of identifying biomarkers in the diagnosis and …

The complex pathobiology underlying cardiovascular diseases (CVDs) has yet to be
explained. Aberrant epigenetic changes may result from alterations in enzymatic activities …

Helminths, allergens, and certain protists induce type 2 immune responses, but the
underlying mechanisms of immune activation remain poorly understood. In the small …

In the preceding decades, molecular characterization has revolutionized breast cancer (BC)
research and therapeutic approaches. Presented herein, an unbiased analysis of breast …

PatternLab for proteomics is an integrated computational environment that unifies several
previously published modules for the analysis of shotgun proteomic data. The contained …

The complexity of the functional proteome extends considerably beyond the coding genome,
resulting in millions of proteoforms. Investigation of proteoforms and their functional roles is …

Introduction Emerging evidence suggests that the essence of life is the ecological balance of
the neural, endocrine, metabolic, microbial, and immune systems. Gut microbiota have been …

Sequence database search engines are bioinformatics algorithms that identify peptides from
tandem mass spectra using a reference protein sequence database. Two decades of …

Metabolomics is a key approach in modern functional genomics and systems biology. Due
to the complexity of metabolomics data, the variety of experimental designs, and the …

Eukaryotic initiation factor 4A-III (eIF4A3), a core helicase component of the exon junction
complex, is essential for splicing, mRNA trafficking, and nonsense-mediated decay …