Orientation of surface immobilized capture proteins, such as antibodies, plays a critical role
in the performance of immunoassays. The sensitivity of immunodiagnostic procedures is …

This review aims at answering the following question: how can a researcher be sure to
succeed in grafting a protein onto a polymer surface? Even if protein immobilization on solid …

We present the development of an analytical model that can be used for the rational design
of a biosensor based on shifts in the local surface plasmon resonance (LSPR) of individual …

In 2007, 1179 papers were published that involved the application of optical biosensors.
Reported developments in instrument hardware, assay design, and immobilization …

Over the last 10 or so years, developments in molecular se-condary ion mass spectrometry
(SIMS) have taken its capability into areas previously only demonstrated in dynamic SIMS …

This concise tutorial review provides a description of the current state of the art in the
application of time-of flight based secondary ion mass spectrometry (TOF-SIMS) in the field …

The review describes methods available for analyzing mineralization of bone tissue in
healing of fractures and implants in bone. The recent development of imaging MS, TOF …

Cryoprotectants such as antifreeze proteins (AFPs) and sugar molecules may provide a
solution for icing problems. These anti-icing substances protect cells and tissues from …

The surface of a material is rapidly covered with proteins once that material is placed in a
biological environment. The structure and function of these bound proteins play a key role in …

The ability to orient active proteins on surfaces is a critical aspect of many medical
technologies. An important related challenge is characterizing protein orientation in these …