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Inflammatory biomarkers for mood disorders-a brief narrative review
Background: The nervous system and the immune system interact consistently in the brain
and peripheries. Inflammation in the brain not only alters the metabolism of …
and peripheries. Inflammation in the brain not only alters the metabolism of …
Development of a novel neuro-immune and opioid-associated fingerprint with a cross-validated ability to identify and authenticate unknown patients with major …
Major depressive disorder (MDD) is characterized by signaling aberrations in interleukin (IL)-
6, IL-10, beta-endorphins as well as μ (MOR) and κ (KOR) opioid receptors. Here we …
6, IL-10, beta-endorphins as well as μ (MOR) and κ (KOR) opioid receptors. Here we …
Serum levels of mu-opioid receptor according to menstrual cycle phases are associated with postoperative pain and opioid consumption in laparoscopic …
Aims In this prospective observational clinical study, we aimed to evaluate the relationship
between serum mu-opioid receptor (MOR) levels according to menstrual cycle phases on …
between serum mu-opioid receptor (MOR) levels according to menstrual cycle phases on …
Compositions and methods for the treatment of depression
M Schmidt, V Popova, A Savitz, R Melkote… - US Patent …, 2024 - Google Patents
The disclosure provides methods for treating major depressive disorder in a human patient
having moderate or severe anhedonia. The methods comprise administering to the patient …
having moderate or severe anhedonia. The methods comprise administering to the patient …
Compositions and methods for the treatment of depression
M Schmidt, V Popova, A Savitz, R Melkote… - US Patent …, 2024 - Google Patents
The disclosure provides methods for treating major depressive disorder in a human patient
having moderate or severe anhedonia. The methods comprise administering to the patient …
having moderate or severe anhedonia. The methods comprise administering to the patient …
Forms of aticaprant
P Fernandes, M Schmidt, V Popova, A Savitz… - US Patent …, 2024 - Google Patents
The disclosure provides crystalline and amorphous forms of aticaprant. Also provided by the
disclosure are pharmaceutical compositions comprising the amorphous or crystalline forms …
disclosure are pharmaceutical compositions comprising the amorphous or crystalline forms …