A review on microfluidic-assisted nanoparticle synthesis, and their applications using multiscale simulation methods

A Agha, W Waheed, I Stiharu, V Nerguizian… - Discover Nano, 2023 - Springer
Recent years have witnessed an increased interest in the development of nanoparticles
(NPs) owing to their potential use in a wide variety of biomedical applications, including drug …

[HTML][HTML] High-throughput manufacturing of size-tuned liposomes by a new microfluidics method using enhanced statistical tools for characterization

E Kastner, R Kaur, D Lowry, B Moghaddam… - International journal of …, 2014 - Elsevier
Microfluidics has recently emerged as a new method of manufacturing liposomes, which
allows for reproducible mixing in miliseconds on the nanoliter scale. Here we investigate …

Nanotherapeutic heterogeneity: sources, effects, and solutions

J Morla‐Folch, A Ranzenigo, ZA Fayad, AJP Teunissen - Small, 2024 - Wiley Online Library
Nanomaterials have revolutionized medicine by enabling control over drugs'
pharmacokinetics, biodistribution, and biocompatibility. However, most nanotherapeutic …

Continuous flow production of cationic liposomes at high lipid concentration in microfluidic devices for gene delivery applications

TA Balbino, NT Aoki, AAM Gasperini… - Chemical engineering …, 2013 - Elsevier
Microfluidics is a powerful technology that allows the production of cationic liposomes by the
hydrodynamic focusing method. We first studied a single hydrodynamic focusing (SHF) …

Interactions of hydrophilic quantum dots with defect-free and defect containing supported lipid membranes

L Bar, F Perissinotto, L Redondo-Morata… - Colloids and Surfaces B …, 2022 - Elsevier
Quantum dots (QDs) are semiconductor nanoparticles with unique optical and electronic
properties, whose interest as potential nano-theranostic platforms for imaging and sensing is …

[HTML][HTML] Cationic pH-sensitive liposomes as tuberculosis subunit vaccine delivery systems: Effect of liposome composition on cellular innate immune responses

MM Szachniewicz, KE van Meijgaarden… - International …, 2025 - Elsevier
Tuberculosis (TB) is a major global health problem, and the development of effective and
safe vaccines is urgently needed. CD8+ T-cells play an important role alongside CD4+ T …

Liposomes prepared in absence of organic solvents: sonication versus lipid film hydration method

MJ De Jesús Valle… - Current Pharmaceutical …, 2015 - ingentaconnect.com
Context: Liposomes appear as an excellent vehicle for parenteral and non-parenteral
administration routes. Drugs, genetic vaccines or skin care products, are candidates to be …

Cationic liposomes produced via ethanol injection method for dendritic cell therapy

MT Vitor, PC Bergami-Santos… - Journal of liposome …, 2017 - Taylor & Francis
Cationic liposomes can be designed and developed in order to be an efficient gene delivery
system for mammalian cells. Dendritic cell (DC) vaccines can be used to treat cancer, as …

Tracking the evolution of transiently transfected individual cells in a microfluidic platform

MT Vitor, S Sart, A Barizien, LGDL Torre, CN Baroud - Scientific reports, 2018 - nature.com
Transient gene expression (TGE) technology enables the rapid production of large amount
of recombinant proteins, without the need of fastidious screening of the producing cells …

Mitotane liposomes for potential treatment of adrenal cortical carcinoma: ex vivo intestinal permeation and in vivo bioavailability

P Zancanella, DML Oliveira, BH de Oliveira… - Pharmaceutical …, 2020 - Taylor & Francis
The adrenal cortical carcinoma (ACC) treatment, for which mitotane (o, p′-DDD) is the drug
of choice, still remains a challenge both because of the well-known solubility problems of the …