Rho GTPases are key regulators of cytoskeletal dynamics and affect many cellular
processes, including cell polarity, migration, vesicle trafficking and cytokinesis. These …

The fusion of myoblasts into multinucleate syncytia plays a fundamental role in muscle
function, as it supports the formation of extended sarcomeric arrays, or myofibrils, within a …

Choosing the right nutrients to consume is essential to health and wellbeing across species.
However, the factors that influence these decisions are poorly understood. This is …

We describe a genetic mosaic system in Drosophila, in which a dominant repressor of a cell
marker is placed in trans to a mutant gene of interest. Mitotic recombination events between …

Forward genetic screens in model organisms have provided important insights into
numerous aspects of development, physiology and pathology. With the availability of …

Small GTP-binding proteins (G proteins) exist in eukaryotes from yeast to human and
constitute a superfamily consisting of more than 100 members. This superfamily is …

Excess adipose fat accumulation, or obesity, is a growing problem worldwide in terms of
both the rate of incidence and the severity of obesity-associated metabolic disease. Adipose …

The Rho GTPases form a subgroup of the Ras superfamily of 20-to 30-kD GTP-binding
proteins that have been shown to regulate a wide spectrum of cellular functions. These …

Rho GTPases control many aspects of cell behavior through the regulation of multiple signal
transduction pathways (Van Aelst and D'Souza-Schorey 1997; Hall 1998). Rho, Rac, and …

Tetanus toxin cleaves the synaptic vesicle protein synaptobrevin, and the ensuing loss of
neurotransmitter exocytosis has implicated synaptobrevin in this process. To further the …