Coordinating gene expression during the cell cycle
Cell cycle-dependent gene transcription is tightly controlled by the retinoblastoma (RB): E2F
and DREAM complexes, which repress all cell cycle genes during quiescence. Cyclin …
and DREAM complexes, which repress all cell cycle genes during quiescence. Cyclin …
Cell cycle transcription control: DREAM/MuvB and RB-E2F complexes
The precise timing of cell cycle gene expression is critical for the control of cell proliferation;
de-regulation of this timing promotes the formation of cancer and leads to defects during …
de-regulation of this timing promotes the formation of cancer and leads to defects during …
Non-canonical functions of the RB protein in cancer
The canonical model of RB-mediated tumour suppression developed over the past 30 years
is based on the regulation of E2F transcription factors to restrict cell cycle progression …
is based on the regulation of E2F transcription factors to restrict cell cycle progression …
DREAM and RB cooperate to induce gene repression and cell-cycle arrest in response to p53 activation
Most human cancers acquire mutations causing defects in the p53 signaling pathway. The
tumor suppressor p53 becomes activated in response to genotoxic stress and is essential for …
tumor suppressor p53 becomes activated in response to genotoxic stress and is essential for …
DREAM on: cell cycle control in development and disease
Perfectly orchestrated periodic gene expression during cell cycle progression is essential for
maintaining genome integrity and ensuring that cell proliferation can be stopped by …
maintaining genome integrity and ensuring that cell proliferation can be stopped by …
The putative tumour suppressor miR-1-3p modulates prostate cancer cell aggressiveness by repressing E2F5 and PFTK1
SM Li, HL Wu, X Yu, K Tang, SG Wang, ZQ Ye… - Journal of Experimental & …, 2018 - Springer
Background Previous studies report that miR-1-3p, a member of the microRNA-1 family (miR-
1), and functions as a tumor suppressor in several different cancers. However, little is known …
1), and functions as a tumor suppressor in several different cancers. However, little is known …
The DREAM complex through its subunit Lin37 cooperates with Rb to initiate quiescence
The retinoblastoma Rb protein is an important factor controlling the cell cycle. Yet,
mammalian cells carrying Rb deletions are still able to arrest under growth-limiting …
mammalian cells carrying Rb deletions are still able to arrest under growth-limiting …
Phosphosite scanning reveals a complex phosphorylation code underlying CDK-dependent activation of Hcm1
Ordered cell cycle progression is coordinated by cyclin dependent kinases (CDKs). CDKs
often phosphorylate substrates at multiple sites clustered within disordered regions …
often phosphorylate substrates at multiple sites clustered within disordered regions …
Short linear motif core and flanking regions modulate retinoblastoma protein binding affinity and specificity
Pocket proteins retinoblastoma (pRb), p107 and p130 are negative regulators of cellular
proliferation and multifunctional proteins regulating development, differentiation and …
proliferation and multifunctional proteins regulating development, differentiation and …
Loss of the Caenorhabditis elegans pocket protein LIN-35 reveals MuvB's innate function as the repressor of DREAM target genes
PD Goetsch, JM Garrigues, S Strome - PLoS genetics, 2017 - journals.plos.org
The DREAM (Dp/Retinoblastoma (Rb)-like/E2F/MuvB) transcriptional repressor complex
acts as a gatekeeper of the mammalian cell cycle by establishing and maintaining cellular …
acts as a gatekeeper of the mammalian cell cycle by establishing and maintaining cellular …