Glucagon-like peptide 1 receptor agonists: cardiovascular benefits and mechanisms of action

JR Ussher, DJ Drucker - Nature Reviews Cardiology, 2023 - nature.com
Type 2 diabetes mellitus (T2DM) and obesity are metabolic disorders characterized by
excess cardiovascular risk. Glucagon-like peptide 1 (GLP1) receptor (GLP1R) agonists …

Myocardial ischemia-reperfusion injury: a neglected therapeutic target

DJ Hausenloy, DM Yellon - The Journal of clinical …, 2013 - Am Soc Clin Investig
Acute myocardial infarction (MI) is a major cause of death and disability worldwide. In
patients with MI, the treatment of choice for reducing acute myocardial ischemic injury and …

Vascular inflammation and oxidative stress: major triggers for cardiovascular disease

S Steven, K Frenis, M Oelze, S Kalinovic… - Oxidative medicine …, 2019 - Wiley Online Library
Cardiovascular disease is a leading cause of death and reduced quality of life, proven by
the latest data of the Global Burden of Disease Study, and is only gaining in prevalence …

The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: a continual challenge

G Heusch, BJ Gersh - European heart journal, 2017 - academic.oup.com
The incidence of ST segment elevation myocardial infarction (STEMI) has decreased over
the last two decades in developed countries, but mortality from STEMI despite widespread …

JCS 2018 guideline on diagnosis and treatment of acute coronary syndrome

K Kimura, T Kimura, M Ishihara, Y Nakagawa… - Circulation …, 2019 - jstage.jst.go.jp
Acute coronary syndromes (ACS) are a comprehensive disease concept characterized by
acute myocardial ischemia caused by disruption of coronary artery plaque and consequent …

Ischaemic conditioning and reperfusion injury

DJ Hausenloy, DM Yellon - Nature Reviews Cardiology, 2016 - nature.com
The 30-year anniversary of the discovery of'ischaemic preconditioning'is in 2016. This
endogenous phenomenon can paradoxically protect the heart from acute myocardial …

Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery

DJ Hausenloy, JA Barrabes, HE Bøtker… - Basic research in …, 2016 - Springer
To commemorate the auspicious occasion of the 30th anniversary of IPC, leading pioneers
in the field of cardioprotection gathered in Barcelona in May 2016 to review and discuss the …

Novel targets and future strategies for acute cardioprotection: Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart

DJ Hausenloy, D Garcia-Dorado… - Cardiovascular …, 2017 - academic.oup.com
Ischaemic heart disease and the heart failure that often results, remain the leading causes of
death and disability in Europe and worldwide. As such, in order to prevent heart failure and …

Optimized treatment of ST-elevation myocardial infarction: the unmet need to target coronary microvascular obstruction as primary treatment goal to further improve …

G Niccoli, RA Montone, B Ibanez, H Thiele… - Circulation …, 2019 - Am Heart Assoc
Primary percutaneous coronary intervention is nowadays the preferred reperfusion strategy
for patients with acute ST-segment–elevation myocardial infarction, aiming at restoring …

Myocardial reperfusion injury: looking beyond primary PCI

GM Fröhlich, P Meier, SK White, DM Yellon… - European heart …, 2013 - academic.oup.com
Coronary heart disease (CHD) is the leading cause of death and disability in Europe. For
patients presenting with an acute ST-segment elevation myocardial infarction (STEMI) …