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NAD+ in brain aging and neurodegenerative disorders
NAD+ is a pivotal metabolite involved in cellular bioenergetics, genomic stability,
mitochondrial homeostasis, adaptive stress responses, and cell survival. Multiple NAD+ …
mitochondrial homeostasis, adaptive stress responses, and cell survival. Multiple NAD+ …
Niacin in the central nervous system: an update of biological aspects and clinical applications
V Gasperi, M Sibilano, I Savini, MV Catani - International journal of …, 2019 - mdpi.com
Niacin (also known as “vitamin B3” or “vitamin PP”) includes two vitamers (nicotinic acid and
nicotinamide) giving rise to the coenzymatic forms nicotinamide adenine dinucleotide (NAD) …
nicotinamide) giving rise to the coenzymatic forms nicotinamide adenine dinucleotide (NAD) …
[HTML][HTML] Nicotinamide riboside—the current state of research and therapeutic uses
Nicotinamide riboside (NR) has recently become one of the most studied nicotinamide
adenine dinucleotide (NAD+) precursors, due to its numerous potential health benefits …
adenine dinucleotide (NAD+) precursors, due to its numerous potential health benefits …
Functions of the sirtuin deacylase SIRT5 in normal physiology and pathobiology
Sirtuins are NAD+-dependent protein deacylases/ADP-ribosyltransferases that have
emerged as candidate targets for new therapeutics to treat metabolic disorders and other …
emerged as candidate targets for new therapeutics to treat metabolic disorders and other …
Reactive astrocytes and therapeutic potential in focal ischemic stroke
Astrocytes are specialized and the most abundant cell type in the central nervous system
(CNS). They play important roles in the physiology of the brain. Astrocytes are also critically …
(CNS). They play important roles in the physiology of the brain. Astrocytes are also critically …
Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging
Neural stem/progenitor cell (NSPC) proliferation and self‐renewal, as well as insult‐induced
differentiation, decrease markedly with age. The molecular mechanisms responsible for …
differentiation, decrease markedly with age. The molecular mechanisms responsible for …
Visfatin/Nampt: an adipokine with cardiovascular impact
T Romacho, CF Sánchez-Ferrer… - Mediators of …, 2013 - Wiley Online Library
Adipose tissue is acknowledged as an endocrine organ that releases bioactive factors
termed adipokines. Visfatin was initially identified as a novel adipokine with insulin‐mimetic …
termed adipokines. Visfatin was initially identified as a novel adipokine with insulin‐mimetic …
Histological, cellular and behavioral assessments of stroke outcomes after photothrombosis-induced ischemia in adult mice
Background Following the onset of focal ischemic stroke, the brain experiences a series of
alterations including infarct evolvement, cellular proliferation in the penumbra, and …
alterations including infarct evolvement, cellular proliferation in the penumbra, and …
Nicotinamide mononucleotide inhibits post-ischemic NAD+ degradation and dramatically ameliorates brain damage following global cerebral ischemia
Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor for multiple cellular
metabolic reactions and has a central role in energy production. Brain ischemia depletes …
metabolic reactions and has a central role in energy production. Brain ischemia depletes …
Visualizing cell death in experimental focal cerebral ischemia: promises, problems, and perspectives
One of the hallmarks of stroke pathophysiology is the widespread death of many different
types of brain cells. As our understanding of the complex disease that is stroke has grown, it …
types of brain cells. As our understanding of the complex disease that is stroke has grown, it …