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WNT signaling in cardiac and vascular disease
WNT signaling is an elaborate and complex collection of signal transduction pathways
mediated by multiple signaling molecules. WNT signaling is critically important for …
mediated by multiple signaling molecules. WNT signaling is critically important for …
Mitochondria in endothelial cells angiogenesis and function: current understanding and future perspectives
Endothelial cells (ECs) angiogenesis is the process of sprouting new vessels from the
existing ones, playing critical roles in physiological and pathological processes such as …
existing ones, playing critical roles in physiological and pathological processes such as …
Epigenetic-sensitive pathways in personalized therapy of major cardiovascular diseases
The complex pathobiology underlying cardiovascular diseases (CVDs) has yet to be
explained. Aberrant epigenetic changes may result from alterations in enzymatic activities …
explained. Aberrant epigenetic changes may result from alterations in enzymatic activities …
Anti-aging genes improve appetite regulation and reverse cell senescence and apoptosis in global populations
IJ Martins - 2016 - ro.ecu.edu.au
Appetite regulation by nutritional intervention is required early in life that involves the anti-
aging gene Sirtuin 1 (Sirt 1) with Sirt 1 maintenance of other cellular anti-aging genes …
aging gene Sirtuin 1 (Sirt 1) with Sirt 1 maintenance of other cellular anti-aging genes …
Molecular mechanisms of endothelial dysfunction in coronary microcirculation dysfunction
Z Zhang, X Li, J He, S Wang, J Wang, J Liu… - Journal of Thrombosis …, 2023 - Springer
Coronary microvascular endothelial cells (CMECs) react to changes in coronary blood flow
and myocardial metabolites and regulate coronary blood flow by balancing vasoconstrictors …
and myocardial metabolites and regulate coronary blood flow by balancing vasoconstrictors …
Histone and DNA methylation–mediated epigenetic downregulation of endothelial Kruppel-like factor 2 by low-density lipoprotein cholesterol
Objective—Low-density lipoprotein (LDL) cholesterol induces endothelial dysfunction and is
a major modifiable risk factor for coronary heart disease. Endothelial Kruppel-like Factor 2 …
a major modifiable risk factor for coronary heart disease. Endothelial Kruppel-like Factor 2 …
Epigenetic Modification in Coronary Atherosclerosis: JACC Review Topic of the Week
Coronary artery disease (CAD) and its major complication, acute myocardial infarction (AMI),
are the leading causes of disability and death worldwide. An individual's risk of develo** …
are the leading causes of disability and death worldwide. An individual's risk of develo** …
Nitric Oxide, Oxidative Stress, and p66Shc Interplay in Diabetic Endothelial Dysfunction
Increased oxidative stress and reduced nitric oxide (NO) bioavailability play a causal role in
endothelial cell dysfunction occurring in the vasculature of diabetic patients. In this review …
endothelial cell dysfunction occurring in the vasculature of diabetic patients. In this review …
[HTML][HTML] Epigenetic mechanisms in vascular inflammation: modulation of endothelial adhesion molecules and endothelium-leukocyte adhesion
The endothelium, an essential component of the vascular system, plays a critical role in the
inflammatory response. Under pro-inflammatory stimuli, endothelial cells undergo activation …
inflammatory response. Under pro-inflammatory stimuli, endothelial cells undergo activation …
Structure-functional implications of longevity protein p66Shc in health and disease
ShcA (Src homologous-collagen homologue), family of adapter proteins, consists of three
isoforms which integrate and transduce external stimuli to different signaling networks. ShcA …
isoforms which integrate and transduce external stimuli to different signaling networks. ShcA …