Overcoming antibiotic resistance: the potential and pitfalls of drug repurposing
M Abavisani, A Khoshrou, S Eshaghian… - Journal of Drug …, 2024 - Taylor & Francis
Since its emergence shortly after the discovery of penicillin, antibiotic resistance has
escalated dramatically, posing a significant health threat and economic burden. Drug …
escalated dramatically, posing a significant health threat and economic burden. Drug …
[HTML][HTML] Laser irradiated phenothiazines: New potential treatment for COVID-19 explored by molecular docking
The worldwide infection with the new Severe Acute Respiratory Syndrome coronavirus 2
(SARS-CoV-2) demands urgently new potent treatment (s). In this study we predict, using …
(SARS-CoV-2) demands urgently new potent treatment (s). In this study we predict, using …
[HTML][HTML] Analyses on the reactivity, topology and bioactivity of fluazinam using density functional theory
R Godwini, JC Monicka, SG Victoria - Chemical Physics Impact, 2023 - Elsevier
Quantum chemical computations were initiated to perform geometry optimization of
Fluazinam by B3LYP/6–311++ G (d, p) basis set employing the DFT approach. Sample of …
Fluazinam by B3LYP/6–311++ G (d, p) basis set employing the DFT approach. Sample of …
Design, synthesis, molecular modeling, biological activity, and mechanism of action of novel amino acid derivatives of norfloxacin
AM Kamal El-sagheir, I Abdelmesseh Nekhala… - ACS …, 2023 - ACS Publications
Two series of N 4-substituted piperazinyl amino acid derivatives of norfloxacin (24 new
compounds) were designed and synthesized to attain structural surrogates with additional …
compounds) were designed and synthesized to attain structural surrogates with additional …
In silico prediction, characterization and molecular docking studies on new benzamide derivatives
Recent research papers have confirmed the prevalence of microorganisms resistant to
numerous antimicrobial agents, leading to spreading infections, extended hospitalizations …
numerous antimicrobial agents, leading to spreading infections, extended hospitalizations …
Structure-guided design and synthesis of C22-and C32-modified FK520 analogs with enhanced activity against human pathogenic fungi
PA Dome, P Jeong, G Nam, H Jang, A Rivera… - Proceedings of the …, 2025 - pnas.org
Invasive fungal infections are a leading cause of death worldwide. Translating molecular
insights into clinical benefits is challenging because fungal pathogens and their hosts share …
insights into clinical benefits is challenging because fungal pathogens and their hosts share …
The Metabolic Potential of Endophytic Actinobacteria Associated with Medicinal Plant Thymus roseus as a Plant-Growth Stimulator
OAA Mohamad, YH Liu, Y Huang, L Li, JB Ma… - Microorganisms, 2022 - mdpi.com
Bio-fertilizer practice considers not only economical but also environmentally friendly,
sustainable agriculture. Endophytes can play important beneficiary roles in plant …
sustainable agriculture. Endophytes can play important beneficiary roles in plant …
Laser-irradiated chlorpromazine as a potent anti-biofilm agent for coating of biomedical devices
Nowadays, antibiotic resistance has become increasingly common, triggering a global
health crisis, immediately needing alternative, including repurposed drugs with potent …
health crisis, immediately needing alternative, including repurposed drugs with potent …
Synthesis and bioinformatic characterization of new Schiff bases with possible applicability in brain disorders
(1) Background: The research aims to find new treatments for neurodegenerative diseases,
in particular, Alzheimer's disease.(2) Methods: This article presents a bioinformatics and …
in particular, Alzheimer's disease.(2) Methods: This article presents a bioinformatics and …
RETRACTED ARTICLE: Molecular docking simulation, drug-likeness assessment, and pharmacokinetic study of some cephalosporin analogues against a penicillin …
In pursuit of novel antibiotics that could curb the growing trend of multidrug resistance by
Salmonella typhimurium, a data set of some cephalosporin analogues were subjected to …
Salmonella typhimurium, a data set of some cephalosporin analogues were subjected to …