The systematic generation of neurons from patients with neurological disorders can provide
important insights into disease pathology, progression and mechanism. This review will …

We demonstrate ensemble three-dimensional cell cultures and quantitative analysis of
angiogenic growth from uniform endothelial monolayers. Our approach combines two key …

Promoting axon regeneration following injury is one of the ultimate challenges of
neuroscience, and understanding the mechanisms that regulate axon growth and guidance …

G-protein–coupled receptor (GPCR) activity gradients evoke important cell behavior but
there is a dearth of methods to induce such asymmetric signaling in a cell. Here we …

In this paper we present compartmentalized neuron arraying (CNA) microfluidic circuits for
the preparation of neuronal networks using minimal cellular inputs (10–100-fold less than …

Hydrogels have shown potential in replacing damaged nerve tissue, but the ideal hydrogel
is yet to be found. In this study, various commercially available hydrogels were compared …

Engineering vasculature networks in physiologically relevant hydrogels represents a
challenge in terms of both fabrication, due to the cell–bioink interactions, as well as the …

Protein micropatterning is a powerful tool for studying the effects of extracellular signals on
cell development and regeneration. Laser micropatterning of proteins is the most flexible …

Tissues contain exquisite vascular microstructures, and patterns of chemical cues for
directing cell migration, homing, and differentiation for organ development and function. 3D …

Directional connectivity is required to develop accurate in vitro models of the nervous
system. This research investigated the interaction of murine neuronal outgrowths with …