Pharmaceutical aspects of salt and cocrystal forms of APIs and characterization challenges

PC Vioglio, MR Chierotti, R Gobetto - Advanced Drug Delivery Reviews, 2017 - Elsevier
In recent years many efforts have been devoted to the screening and the study of new solid-
state forms of old active pharmaceutical ingredients (APIs) with salification or co …

[BOOK][B] Isotope effects in chemistry and biology

A Kohen, HH Limbach - 2005 - taylorfrancis.com
The field of isotope effects has expanded exponentially in the last decade, and researchers
are finding isotopes increasingly useful in their studies. Bringing literature on the subject up …

Pyridine-15N A Mobile NMR Sensor for Surface Acidity and Surface Defects of Mesoporous Silica

IG Shenderovich, G Buntkowsky… - The Journal of …, 2003 - ACS Publications
The hydrogen bond interaction of pyridine with the silanol groups of the inner surfaces of
MCM-41 and SBA-15 ordered mesoporous silica has been studied by a combination of solid …

Interrogating the Lewis Acidity of Metal Sites in Beta Zeolites with 15N Pyridine Adsorption Coupled with MAS NMR Spectroscopy

WR Gunther, VK Michaelis, RG Griffin… - The Journal of …, 2016 - ACS Publications
The Lewis acidity of isolated framework metal sites in Beta zeolites was characterized with
15N isotopically labeled pyridine adsorption coupled with magic-angle spinning nuclear …

How strong is hydrogen bonding in ionic liquids? Combined X-ray crystallographic, infrared/Raman spectroscopic, and density functional theory study

SA Katsyuba, MV Vener, EE Zvereva… - The Journal of …, 2013 - ACS Publications
Hydrogen bonding in ionic liquids based on the 1-(2′-hydroxylethyl)-3-methylimidazolium
cation ([C2OHmim]+) and various anions ([A]−) of differing H-bond acceptor strength, viz …

Solid-State Acid−Base Interactions in Complexes of Heterocyclic Bases with Dicarboxylic Acids:  Crystallography, Hydrogen Bond Analysis, and 15N NMR …

ZJ Li, Y Abramov, J Bordner, J Leonard… - Journal of the …, 2006 - ACS Publications
A cancer candidate, compound 1, is a weak base with two heterocyclic basic nitrogens and
five hydrogen-bonding functional groups, and is sparingly soluble in water rendering it …

Probing Hydrogen Bonding in Cocrystals and Amorphous Dispersions Using 14N–1H HMQC Solid-State NMR

AS Tatton, TN Pham, FG Vogt, D Iuga… - Molecular …, 2013 - ACS Publications
Cocrystals and amorphous solid dispersions have generated interest in the pharmaceutical
industry as an alternative to more established solid delivery forms. The identification of …

Natural Abundance 17O DNP NMR Provides Precise O−H Distances and Insights into the Brønsted Acidity of Heterogeneous Catalysts

FA Perras, Z Wang, P Naik, II Slowing… - Angewandte …, 2017 - Wiley Online Library
Heterogeneous Brønsted acid catalysts are tremendously important in industry, particularly
in catalytic cracking processes. Here we show that these Brønsted acid sites can be directly …

OHO hydrogen bond geometries and NMR chemical shifts: from equilibrium structures to geometric H/D isotope effects, with applications for water, protonated water …

HH Limbach, PM Tolstoy… - Israel Journal of …, 2009 - Wiley Online Library
Hydrogen bond geometries and 1 H NMR chemical shifts of OHO hydrogen‐bonded
systems have been analyzed using an improved valence bond order model. This model …

Low-temperature NMR studies of the structure and dynamics of a novel series of acid− base complexes of HF with collidine exhibiting scalar couplings across …

IG Shenderovich, PM Tolstoy, NS Golubev… - Journal of the …, 2003 - ACS Publications
The low-temperature 1H, 19F, and 15N NMR spectra of mixtures of collidine-15N (2, 4, 6-
trimethylpyridine-15N, Col) with HF have been measured using CDF3/CDF2Cl as a solvent …