Omega‐3 polyunsaturated fatty acids and hypertension: A review of vasodilatory mechanisms of docosahexaenoic acid and eicosapentaenoic acid

CI Bercea, GS Cottrell, F Tamagnini… - British Journal of …, 2021 - Wiley Online Library
Hypertension is often characterised by impaired vasodilation involving dysfunction of
multiple vasodilatory mechanisms. ω‐3 polyunsaturated fatty acids (PUFAs) …

Endothelium-dependent hyperpolarization (EDH) in hypertension: the role of endothelial ion channels

K Goto, T Ohtsubo, T Kitazono - International Journal of Molecular …, 2018 - mdpi.com
Upon stimulation with agonists and shear stress, the vascular endothelium of different
vessels selectively releases several vasodilator factors such as nitric oxide and prostacyclin …

[HTML][HTML] Hypotensive and vasorelaxant effects of sanguisorbae radix ethanol extract in spontaneously hypertensive and sprague dawley rats

J Jung, S Shin, J Park, K Lee, HY Choi - Nutrients, 2023 - mdpi.com
Hypertension requires proper management because of the increased risk of cardiovascular
disease and death. For this purpose, functional foods containing tannins have been …

Cellular and molecular effects of hyperglycemia on ion channels in vascular smooth muscle

M Nieves-Cintrón, VA Flores-Tamez, T Le… - Cellular and Molecular …, 2021 - Springer
Diabetes affects millions of people worldwide. This devastating disease dramatically
increases the risk of develo** cardiovascular disorders. A hallmark metabolic abnormality …

Vascular smooth muscle ion channels in essential hypertension

N Daghbouche-Rubio, JR López-López… - Frontiers in …, 2022 - frontiersin.org
Hypertension is a highly prevalent chronic disease and the major risk factor for
cardiovascular diseases, the leading cause of death worldwide. Hypertension is …

Hydrogen sulfide-induced vasodilation: the involvement of vascular potassium channels

XY Liu, LL Qian, RX Wang - Frontiers in pharmacology, 2022 - frontiersin.org
Hydrogen sulfide (H2S) has been highlighted as an important gasotransmitter in mammals.
A growing number of studies have indicated that H2S plays a key role in the …

Cerebral arteriolar and neurovascular dysfunction after chemically induced menopause in mice

JA Blackwell, JF Silva, EM Louis… - American Journal …, 2022 - journals.physiology.org
Cognitive decline is linked to decreased cerebral blood flow, particularly in women after
menopause. Impaired cerebrovascular function precedes the onset of dementia, possibly …

Role of PVAT in obesity-related cardiovascular disease through the buffering activity of ATF3

HF Li, HT Liu, PY Chen, H Lin, TL Tseng - Iscience, 2022 - cell.com
Thoracic aortic perivascular adipose tissue (PVAT) is an adipose organ exhibiting
similarities to brown adipose tissue (BAT), including cellular morphology and thermogenic …

Adenylyl cyclase 5–generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia

AU Syed, GR Reddy, D Ghosh, MP Prada… - The Journal of clinical …, 2019 - jci.org
Elevated blood glucose (hyperglycemia) is a hallmark metabolic abnormality in diabetes.
Hyperglycemia is associated with protein kinase A–dependent (PKA-dependent) stimulation …

Diminazene aceturate uses different pathways to induce relaxation in healthy and atherogenic blood vessels

LK Gadanec, T Qaradakhi, KR McSweeney… - Biochemical …, 2023 - Elsevier
Diminazene aceturate (DIZE), a putative angiotensin-converting enzyme 2 (ACE2) activator,
elicits relaxation in various animal models. This study aimed to determine the relaxing …