Background Cognitive impairment, including dementia, is a major health concern with the
increasing aging population. Preventive measures to delay cognitive decline are of utmost …

Vitamin B12 deficiency causes a wide range of hematological, gastrointestinal, psychiatric
and neurological disorders. Hematological presentation of cobalamin deficiency ranges …

A preponderance of evidence supports a role for vitamin D beyond the classical function in
mineral homeostasis. Epidemiologic investigations have revealed a beneficial role of …

There are numerous theories of aging, a process which still seems inevitable. Aging leads to
cancer and multi-systemic disorders as well as chronic diseases. Decline in age-associated …

Background: Elevated homocysteine concentrations may contribute to cognitive impairment.
Most elevations in homocysteine result from inadequate folate, vitamin B-12, or vitamin B-6 …

Vitamin B12 is a cofactor of methionine synthase in the synthesis of methionine, the
precursor of the universal methyl donor S-Adenosylmethionine (SAMe), which is involved in …

Dementia has reached epidemic proportions, with an estimated 4.6 million new cases
worldwide each year. With an aging world population, the prevalence of dementia will …

Objectives: To investigate the relationship between markers of vitamin B12 status and brain
volume loss per year over a 5-year period in an elderly population. Methods: A prospective …

Vitamin B12 deficiency is a common cause of neuropsychiatric symptoms in elderly persons.
Malabsorption accounts for the majority of cases. Vitamin B12 deficiency has been …

Nutrition is an important determinant of health in persons over the age of 65. Malnutrition in
the elderly is often underdiagnosed. Careful nutritional assessment is necessary for both the …