With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …

Aminoglycosides are highly potent, broad-spectrum antibiotics that exert their bactericidal
therapeutic effect by selectively binding to the decoding aminoacyl site (A-site) of the …

The classical RNA secondary structure model considers A· U and G· C Watson–Crick as well
as G· U wobble base pairs. Here we substitute it for a new one, in which sets of nucleotide …

Despite the fact that important genetic diseases are caused by mutant mitochondrial
ribosomes, the molecular mechanisms by which such ribosomes result in a clinical …

Recent studies of prokaryotic ribosomes have dramatically increased our knowledge of
ribosomal RNA (rRNA) structure, functional centers, and their interactions with antibiotics …

Structural and genetic studies on prokaryotic ribosomes have provided important insights
into fundamental aspects of protein synthesis and translational control and its interaction …

Aminoglycoside antibiotics interfere with the translation mechanism by binding to the tRNA
decoding site of the 16S ribosomal RNA. Crystallographic structures of aminoglycosides …

Targeting RNA with small molecule drugs is an area of great potential for therapeutic
treatment of infections and possibly genetic and autoimmune diseases. However, a mature …

Premature termination codons (PTCs) are a cause of numerous genetic disorders spanning
diseases that affect children and adults, and are produced by base pair substitutions that …

Although aminoglycoside antibiotics are effective against Gram-negative infections, these
drugs often cause irreversible hearing damage. Binding to the decoding site of the …