Nuclear factor erythroid 2‐related factor 2 (NRF2) is a master transcriptional regulator of
genes whose products defend our cells for toxic and oxidative insults. Although NRF2 …

Aging and cancer are the most important issues to research. The population in the world is
growing older, and the incidence of cancer increases with age. There is no doubt about the …

Cells constantly generate reactive oxygen species (ROS) during aerobic metabolism. The
ROS generation plays an important protective and functional role in the immune system. The …

This year, more than 1 million Americans and more than 10 million people worldwide are
expected to be diagnosed with cancer, a disease commonly believed to be preventable …

Free radicals and other reactive species (RS) are thought to play an important role in many
human diseases. Establishing their precise role requires the ability to measure them and the …

It is increasingly proposed that reactive oxygen species (ROS) and reactive nitrogen species
(RNS) play a key role in human cancer development [1–6], especially as evidence is …

A major development of carcinogenesis research in the past 20 years has been the
discovery of significant levels of DNA damage arising from endogenous cellular sources …

Oxygen derived species such as superoxide radical, hydrogen peroxide, singlet oxygen and
hydroxyl radical are well known to be cytotoxic and have been implicated in the etiology of a …

Free radicals are ubiquitous in our body and are generated by normal physiological
processes, including aerobic metabolism and inflammatory responses, to eliminate invading …

Reactive species are frequently formed after viral infections. Antioxidant defences, including
enzymatic and non-enzymatic components, protect against reactive species, but sometimes …