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Automated and autonomous experiments in electron and scanning probe microscopy
Machine learning and artificial intelligence (ML/AI) are rapidly becoming an indispensable
part of physics research, with domain applications ranging from theory and materials …
part of physics research, with domain applications ranging from theory and materials …
Unsupervised deep learning methods for biological image reconstruction and enhancement: An overview from a signal processing perspective
Recently, deep learning (DL) approaches have become the main research frontier for
biological image reconstruction and enhancement problems thanks to their high …
biological image reconstruction and enhancement problems thanks to their high …
CryoDRGN: reconstruction of heterogeneous cryo-EM structures using neural networks
Cryo-electron microscopy (cryo-EM) single-particle analysis has proven powerful in
determining the structures of rigid macromolecules. However, many imaged protein …
determining the structures of rigid macromolecules. However, many imaged protein …
Adversarial generation of continuous images
In most existing learning systems, images are typically viewed as 2D pixel arrays. However,
in another paradigm gaining popularity, a 2D image is represented as an implicit neural …
in another paradigm gaining popularity, a 2D image is represented as an implicit neural …
Learning structural heterogeneity from cryo-electron sub-tomograms with tomoDRGN
BM Powell, JH Davis - Nature methods, 2024 - nature.com
Cryo-electron tomography (cryo-ET) enables observation of macromolecular complexes in
their native, spatially contextualized cellular environment. Cryo-ET processing software to …
their native, spatially contextualized cellular environment. Cryo-ET processing software to …
Improved transformer for high-resolution gans
Attention-based models, exemplified by the Transformer, can effectively model long range
dependency, but suffer from the quadratic complexity of self-attention operation, making …
dependency, but suffer from the quadratic complexity of self-attention operation, making …
Amortized inference for heterogeneous reconstruction in cryo-EM
Cryo-electron microscopy (cryo-EM) is an imaging modality that provides unique insights
into the dynamics of proteins and other building blocks of life. The algorithmic challenge of …
into the dynamics of proteins and other building blocks of life. The algorithmic challenge of …
A multi-encoder variational autoencoder controls multiple transformational features in single-cell image analysis
Image-based cell phenoty** relies on quantitative measurements as encoded
representations of cells; however, defining suitable representations that capture complex …
representations of cells; however, defining suitable representations that capture complex …
Orientation-invariant autoencoders learn robust representations for shape profiling of cells and organelles
Cell and organelle shape are driven by diverse genetic and environmental factors and thus
accurate quantification of cellular morphology is essential to experimental cell biology …
accurate quantification of cellular morphology is essential to experimental cell biology …
Reconstructing continuous distributions of 3D protein structure from cryo-EM images
Cryo-electron microscopy (cryo-EM) is a powerful technique for determining the structure of
proteins and other macromolecular complexes at near-atomic resolution. In single particle …
proteins and other macromolecular complexes at near-atomic resolution. In single particle …