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Mechanisms of drug-induced tolerance in Mycobacterium tuberculosis
Successful treatment of tuberculosis (TB) can be hampered by Mycobacterium tuberculosis
populations that are temporarily able to survive antibiotic pressure in the absence of drug …
populations that are temporarily able to survive antibiotic pressure in the absence of drug …
Multitalented synthetic antimicrobial peptides and their antibacterial, antifungal and antiviral mechanisms
Despite the great strides in healthcare during the last century, some challenges still
remained unanswered. The development of multi-drug resistant bacteria, the alarming …
remained unanswered. The development of multi-drug resistant bacteria, the alarming …
SICLOPPS cyclic peptide libraries in drug discovery
Highlights•SICLOPPS allows the rapid generation of cyclic peptide libraries in cells.•A
variety of cyclic peptide ring sizes may be generated with SICLOPPS.•SICLOPPS libraries …
variety of cyclic peptide ring sizes may be generated with SICLOPPS.•SICLOPPS libraries …
Resilience in the face of uncertainty: sigma factor B fine-tunes gene expression to support homeostasis in Gram-positive bacteria
Gram-positive bacteria are ubiquitous and diverse microorganisms that can survive and
sometimes even thrive in continuously changing environments. The key to such resilience is …
sometimes even thrive in continuously changing environments. The key to such resilience is …
Identification of Covalent Cyclic Peptide Inhibitors Targeting Protein–Protein Interactions Using Phage Display
Peptide macrocycles are promising therapeutics for a variety of disease indications due to
their overall metabolic stability and potential to make highly selective binding interactions …
their overall metabolic stability and potential to make highly selective binding interactions …
The alternative sigma factors SigE and SigB are involved in tolerance and persistence to antitubercular drugs
The emergence and spread of drug-resistant Mycobacterium tuberculosis strains possibly
threaten our ability to treat this disease in the future. Even though two new antitubercular …
threaten our ability to treat this disease in the future. Even though two new antitubercular …
A high-throughput system to identify inhibitors of Candidatus Liberibacter asiaticus transcription regulators
Citrus greening disease, also known as huanglongbing (HLB), is the most devastating
disease of Citrus worldwide. This incurable disease is caused primarily by the bacterium …
disease of Citrus worldwide. This incurable disease is caused primarily by the bacterium …
[HTML][HTML] Bacterial envelope stress responses: essential adaptors and attractive targets
Millions of deaths a year across the globe are linked to antimicrobial resistant infections. The
need to develop new treatments and repurpose of existing antibiotics grows more pressing …
need to develop new treatments and repurpose of existing antibiotics grows more pressing …
Resistance and tolerance of Mycobacterium tuberculosis to antimicrobial agents—How M. tuberculosis can escape antibiotics
H Li, J Yuan, S Duan, Y Pang - WIREs Mechanisms of Disease, 2022 - Wiley Online Library
Tuberculosis (TB) poses a serious threat to public health worldwide since it was discovered.
Until now, TB has been one of the top 10 causes of death from a single infectious disease …
Until now, TB has been one of the top 10 causes of death from a single infectious disease …
Recent advances in synthesis and identification of cyclic peptides for bioapplications
Cyclic peptides, owing to their good stability, high resistance to exo-and to some extent endo-
peptidases, enhanced binding affinity and selectivity towards target biomolecules, are …
peptidases, enhanced binding affinity and selectivity towards target biomolecules, are …