Same substrate, many reactions: oxygen activation in flavoenzymes
Over time, organisms have evolved strategies to cope with the abundance of dioxygen on
Earth. Oxygen-utilizing enzymes tightly control the reactions involving O2 mostly by …
Earth. Oxygen-utilizing enzymes tightly control the reactions involving O2 mostly by …
Formation and cleavage of C–C bonds by enzymatic oxidation–reduction reactions
Many oxidation–reduction (redox) enzymes, particularly oxygenases, have roles in reactions
that make and break C–C bonds. The list includes cytochrome P450 and other heme-based …
that make and break C–C bonds. The list includes cytochrome P450 and other heme-based …
Metabolic and pharmaceutical aspects of fluorinated compounds
BM Johnson, YZ Shu, X Zhuo… - Journal of medicinal …, 2020 - ACS Publications
The applications of fluorine in drug design continue to expand, facilitated by an improved
understanding of its effects on physicochemical properties and the development of synthetic …
understanding of its effects on physicochemical properties and the development of synthetic …
Baeyer–Villiger monooxygenases: tunable oxidative biocatalysts
Pollution, accidents, and misinformation have earned the pharmaceutical and chemical
industry a poor public reputation, despite their undisputable importance to society …
industry a poor public reputation, despite their undisputable importance to society …
Evolution of enzyme functionality in the flavin-containing monooxygenases
Among the molecular mechanisms of adaptation in biology, enzyme functional
diversification is indispensable. By allowing organisms to expand their catalytic repertoires …
diversification is indispensable. By allowing organisms to expand their catalytic repertoires …
Ancestral-sequence reconstruction unveils the structural basis of function in mammalian FMOs
Flavin-containing monooxygenases (FMOs) are ubiquitous in all domains of life and
metabolize a myriad of xenobiotics, including toxins, pesticides and drugs. However, despite …
metabolize a myriad of xenobiotics, including toxins, pesticides and drugs. However, despite …
Drug metabolism by flavin-containing monooxygenases of human and mouse
IR Phillips, EA Shephard - Expert opinion on drug metabolism & …, 2017 - Taylor & Francis
ABSTRACT Introduction: Flavin-containing monooxygenases (FMOs) play an important role
in drug metabolism. Areas covered: We focus on the role of FMOs in the metabolism of drugs …
in drug metabolism. Areas covered: We focus on the role of FMOs in the metabolism of drugs …
NHR-49/PPAR-α and HLH-30/TFEB cooperate for C. elegans host defense via a flavin-containing monooxygenase
The model organism Caenorhabditis elegans mounts transcriptional defense responses
against intestinal bacterial infections that elicit overlap** starvation and infection …
against intestinal bacterial infections that elicit overlap** starvation and infection …
Predicting regioselectivity of AO, CYP, FMO, and UGT metabolism using quantum mechanical simulations and machine learning
Unexpected metabolism in modification and conjugation phases can lead to the failure of
many late-stage drug candidates or even withdrawal of approved drugs. Thus, it is critical to …
many late-stage drug candidates or even withdrawal of approved drugs. Thus, it is critical to …
Roles of selected non-P450 human oxidoreductase enzymes in protective and toxic effects of chemicals: review and compilation of reactions
SP Rendić, RD Crouch, FP Guengerich - Archives of Toxicology, 2022 - Springer
This is an overview of the metabolic reactions of drugs, natural products, physiological
compounds, and other (general) chemicals catalyzed by flavin monooxygenase (FMO) …
compounds, and other (general) chemicals catalyzed by flavin monooxygenase (FMO) …