Malignantly transformed cells must alter their metabolic status to stay viable in a harsh
microenvironment and maintain their ability to invade and spread. Anoikis, a specific …

As a leading cause of death, second only to heart disease, cancer has always been one of
the burning topics in medical research. When targeting multiple signal pathways in …

Malignant melanoma is a devastating disease. Because of its aggressiveness, it also serves
as a model tumor for investigating novel therapeutic avenues. In recent years, scientific …

Current treatment for patients with metastatic melanoma include molecular-targeted
therapies and immune checkpoint inhibitors. However, a subset of melanomas are difficult-to …

Strategies to improve activity and selectivity are major goals in oncological drug
development. Medical gas plasma therapy has been subject to intense research in …

Diosmetin is a natural flavonoid obtained from citrus fruits and some medicinal herbs.
Previous studies have reported the anti-cancer activity of diosmetin in some types of tumors …

Melanoma is a therapy-resistant skin cancer due to numerous mechanisms supporting cell
survival. Although components of melanoma cytoprotective mechanisms are overexpressed …

Over the last decade, the treatment of tumor patients has been revolutionized by the highly
successful introduction of novel targeted therapies, in particular small-molecule kinase …

Melanoma of the skin has become a prime example for demonstrating the success of
targeted cancer therapy. Nevertheless, high mortality has remained, mainly related to tumor …

The tumor microenvironment is characterized by cancer cell subpopulations with
heterogeneous cell cycle profiles. For example, hypoxic tumor zones contain clusters of …