Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …

The skeletal system is the basis of the vertebral body composition, which affords stabilization
sites for muscle attachment, protects vital organs, stores mineral ions, supplies places to the …

Osteoporosis, is the most common bone disorder worldwide characterized by low bone
mineral density, leaving affected bones vulnerable to fracture. Bone homeostasis depends …

During aging and after traumatic injuries, cartilage and bone cells are exposed to various
pathophysiologic mediators, including reactive oxygen species (ROS), damage-associated …

During food processing, especially heating, the flavor and color of food change to a great
extent due to Maillard reaction (MR). MR is a natural process for improving the flavor in …

ABSTRACT A growing number of studies have shown that melatonin is a potent agonist of
SIRT3 (sirtuin 3) and effectively protects mitochondria, suggesting melatonin as a promising …

Acute kidney injury (AKI) is a serious clinical complication with high morbidity and mortality
rates. Despite substantial progress in understanding the mechanism of AKI, no effective …

Increasing studies have reported that intervertebral disc degeneration (IVDD) is the main
contributor and independent risk factor for low back pain (LBP), it would be, therefore …

Osteoporosis, a metabolic bone disease characterized by low bone mineral density and
deterioration of bone microarchitecture, has led to a high risk of fatal osteoporotic fractures …

Osteoporosis is a widespread systemic disease characterized by a decrease in bone mass
and an imbalance of the microarchitecture of bone tissue. Experimental and clinical studies …