The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …

Drug-induced torsades de pointes (TdP) arrhythmia is a major safety concern in the process
of drug design and development. The incidence of TdP tends to be low, so early pre-clinical …

Cardiac arrhythmias can follow disruption of the normal cellular electrophysiological
processes underlying excitable activity and their tissue propagation as coherent wavefronts …

The content of this article derives from a Health and Environmental Sciences Institute (HESI)
consortium with a focus to improve cardiac safety during drug development. A detailed …

Perception of heat or cold in higher organisms is mediated by specialized ion channels
whose gating is exquisitely sensitive to temperature. The physicochemical underpinnings of …

Cardiac I Kr is a critical repolarizing current in the heart and a target for inherited and
acquired long-QT syndrome (LQTS). Biochemical and functional studies have demonstrated …

Mathematical models of ion channels, which constitute indispensable components of action
potential models, are commonly constructed by fitting to whole-cell patch-clamp data. In a …

The human Ether-a-go-go Related Gene (hERG) potassium channel plays a central role in
regulating cardiac excitability and maintenance of normal cardiac rhythm. Mutations in …

Objective To comprehensively describe the new syndrome of myoclonus epilepsy and
ataxia due to potassium channel mutation (MEAK), including cellular electrophysiological …

The birth and discovery of electrophysiological science took place in the 18 th century laying
the path for our understanding of nerve membrane ionic currents. The pore-forming proteins …