Carotid body chemoreceptors: physiology, pathology, and implications for health and disease

R Iturriaga, J Alcayaga, MW Chapleau… - Physiological …, 2021 - journals.physiology.org
The carotid body (CB) is the main peripheral chemoreceptor for arterial respiratory gases O2
and CO2 and pH, eliciting reflex ventilatory, cardiovascular, and humoral responses to …

[HTML][HTML] Peripheral chemoreceptors: function and plasticity of the carotid body

P Kumar, NR Prabhakar - Comprehensive Physiology, 2012 - ncbi.nlm.nih.gov
The discovery of the sensory nature of the carotid body dates back to the beginning of the
20th century. Following these seminal discoveries, research into carotid body mechanisms …

Neurotransmission in the carotid body: transmitters and modulators between glomus cells and petrosal ganglion nerve terminals

R Iturriaga, J Alcayaga - Brain Research Reviews, 2004 - Elsevier
The carotid body (CB) is the main arterial chemoreceptor. The most accepted model of
arterial chemoreception postulates that carotid body glomus (type I) cells are the primary …

Sensory processing and integration at the carotid body tripartite synapse: neurotransmitter functions and effects of chronic hypoxia

EM Leonard, S Salman, CA Nurse - Frontiers in physiology, 2018 - frontiersin.org
Maintenance of homeostasis in the respiratory and cardiovascular systems depends on
reflexes that are initiated at specialized peripheral chemoreceptors that sense changes in …

Role of acetylcholine in neurotransmission of the carotid body

M Shirahata, A Balbir, T Otsubo… - Respiratory physiology & …, 2007 - Elsevier
Acetylcholine (ACh) has been considered an important excitatory neurotransmitter in the
carotid body (CB). Its physiological and pharmacological effects, metabolism, release, and …

ACh and ATP mediate excitatory transmission in cat carotid identified chemoreceptor units in vitro

R Varas, J Alcayaga, R Iturriaga - Brain research, 2003 - Elsevier
Several molecules have been proposed as excitatory transmitters between glomus (type 1)
cells and nerve terminals of petrosal ganglion (PG) neurons in the carotid body (CB). We …

Carotid body plastic behavior: evidence for D2–H3 receptor–receptor interactions

E Stocco, A Emmi, MM Sfriso, A Tushevski… - Frontiers in …, 2024 - frontiersin.org
Dopamine and histamine receptors D2R and H3R are G protein-coupled receptors (GPCRs)
which can establish physical receptor–receptor interactions (RRIs), leading to homo/hetero …

Neurotransmitters in Carotid Body Function: The Case of Dopamine – Invited Article

R Iturriaga, J Alcayaga, C Gonzalez - Arterial Chemoreceptors: Arterial …, 2009 - Springer
The carotid body (CB) is the main peripheral chemoreceptor. The present model of CB
chemoreception states that glomus (type I) cells are the primary receptors, which are …

Electrical and pharmacological properties of petrosal ganglion neurons that innervate the carotid body

R Iturriaga, R Varas, J Alcayaga - Respiratory physiology & neurobiology, 2007 - Elsevier
The petrosal ganglion (PG) contains the somata of primary afferent neurons that innervate
the chemoreceptor (glomus) cells in the carotid body (CB). The most accepted model of CB …

The impact of hypoxia and low glucose on the release of acetylcholine and ATP from the incubated cat carotid body

RS Fitzgerald, M Shirahata, I Chang, E Kostuk - Brain research, 2009 - Elsevier
The carotid body (CB) is a polymodal sensor which increases its neural output to the
nucleus tractus solitarii with a subsequent activation of several reflex cardiopulmonary …