Obesity remains the most important risk factor for the incidence and progression of
osteoarthritis (OA). The leading cause of OA was believed to be overloading the joints due to …

Abstract The glucagon-like peptide-1 (GLP-1) receptor, known as GLP-1R, is a vital
component of the G protein-coupled receptor (GPCR) family and is found primarily on the …

Inflammation can arise in response to a variety of stimuli, including infectious agents, tissue
injury, autoimmune diseases, and obesity. Some of these responses are acute and resolve …

Constitutive p16 Ink4a expression, along with senescence-associated β-galactosidase
(SAβG), are commonly accepted biomarkers of senescent cells (SCs). Recent reports …

Modulation of tumor-associated macrophages (TAMs) holds promise for cancer treatment,
mainly relying on M1 signaling activation and pro-inflammatory promotion. Nevertheless, the …

Osteoarthritis (OA) is the most common cause of disability in worldwide population, which is
characterized by cartilage breakdown, synovial fibrosis, osteophyte formation and pain …

Bone metabolism is tightly regulated by the immune system. Accelerated bone destruction is
observed in many bone diseases, such as rheumatoid arthritis, fracture, and particle …

The mammalian skeleton is a metabolically active organ that continuously undergoes bone
remodeling, a process of tightly coupled bone resorption and formation throughout life …

Iron oxide nanoparticles (IONPs) have emerging anticancer applications via polarizing
tumor-associated macrophages from tumor-promoting phenotype (M2) to tumor-suppressing …

Osteoarthritis (OA) is a common chronic disease and a significant health concern that needs
to be urgently solved. OA affects the cartilage and entire joint tissues, including the …