The Circulating Proteome─ Technological Developments, Current Challenges, and Future Trends

PE Geyer, D Hornburg, M Pernemalm… - Journal of proteome …, 2024 - ACS Publications
Recent improvements in proteomics technologies have fundamentally altered our capacities
to characterize human biology. There is an ever-growing interest in using these novel …

Engineered nanoparticles for clinical assays

J Cheong, A Jo, J Lee, S Lee, J Lee, JH Lee… - Nature Reviews …, 2024 - nature.com
Nanoparticles exhibit distinctive physical and chemical properties that make them effective
mediators for optical, magnetic or electric signal transduction. Consequently, nanoparticles …

The one hour human proteome

LR Serrano, TM Peters-Clarke, TN Arrey… - Molecular & Cellular …, 2024 - ASBMB
We describe deep analysis of the human proteome in less than 1 h. We achieve this
expedited proteome characterization by leveraging state-of-the-art sample preparation …

[HTML][HTML] Secretome analysis using Affinity Proteomics and Immunoassays: a focus on Tumor Biology

VM Beutgen, V Shinkevich, J Pörschke… - Molecular & Cellular …, 2024 - Elsevier
The study of the cellular secretome using proteomic techniques continues to capture the
attention of the research community across a broad range of topics in biomedical research …

[HTML][HTML] Promises and challenges of populational proteomics in health and disease

BB Sun, K Suhre, BW Gibson - Molecular & Cellular Proteomics, 2024 - Elsevier
Advances in proteomic assay technologies has significantly increased coverage and
throughput, enabling recent increases in the number of large-scale population-based …

[HTML][HTML] A Scaled Proteomic Discovery Study for Prostate Cancer Diagnostic Markers Using ProteographTM and Trapped Ion Mobility Mass Spectrometry

MEK Chang, J Lange, JM Cartier, TW Moore… - International journal of …, 2024 - mdpi.com
There is a significant unmet need for clinical reflex tests that increase the specificity of
prostate-specific antigen blood testing, the longstanding but imperfect tool for prostate …

A genome-wide association study of mass spectrometry proteomics using the Seer Proteograph platform

K Suhre, Q Chen, A Halama, K Mendez, A Dahlin… - …, 2024 - pmc.ncbi.nlm.nih.gov
Genome-wide association studies (GWAS) with proteomics are essential tools for drug
discovery. To date, most studies have used affinity proteomics platforms, which have limited …

[HTML][HTML] Proteomic Profiling Towards a Better Understanding of Genetic Based Muscular Diseases: The Current Picture and a Look to the Future

M Pauper, A Hentschel, M Tiburcy, S Beltran, T Ruck… - Biomolecules, 2025 - mdpi.com
Proteomics accelerates diagnosis and research of muscular diseases by enabling the robust
analysis of proteins relevant for the manifestation of neuromuscular diseases in the following …

Uncovering dark mass in population proteomics: Pan-analysis of single amino acid polymorphism relevant to cognition and aging

X Gao, Y Yin, Y Chen, L Lu, J Zhao, X Lin, J Wu, Q Li… - Cell Genomics, 2025 - cell.com
Human proteome data across populations have been analyzed extensively to reveal protein
quantitative associations with physiological or pathological states, while the single amino …

Reproducible protein quantitation of 270 human proteins at increased depth using nanoparticle-based fractionation and multiple reaction monitoring mass …

C Gaither, R Popp, AS Gajadhar, CH Borchers - Analyst, 2025 - pubs.rsc.org
Here we show that when using a mix of 274 light synthetic peptide standards (NAT) as
surrogates for 270 human plasma proteins, as well as stable isotope-labelled standards …