Background: The upregulated expression of BET proteins is closely associated with the
occurrence and development of hematological malignancies and solid tumors. Several BET …

The oral cavity is often the first site where viruses interact with the human body. The oral
epithelium is a major site of viral entry, replication and spread to other cell types, where …

Bromodomain-selective BET inhibition has emerged as a promising strategy to improve the
safety profiles of pan-BET inhibitors. Herein, we report the discovery of potent phenoxyaryl …

The functions of the bromodomain and extra terminal (BET) family of proteins have been
implicated in a wide range of diseases, particularly in the oncology and immuno …

During recent decades, a great variety of viral and host targets have been exploited for the
discovery of antiviral agents against human infectious diseases. 1 Although significant …

As a member of BET (bromodomain and extra-terminal) protein family, BRD4 (bromodomain-
containing protein 4) is a chromatin-associated protein that interacts with acetylated histones …

Proteins of the bromodomain and exterminal domain (BET) family mediate critical host
functions such as cell proliferation, transcriptional regulation, and the innate immune …

Domain-specific BET bromodomain ligands represent an attractive target for drug discovery
with the potential to unlock the therapeutic benefits of antagonizing these proteins without …

Human Papillomaviruses (HPV) reproduce in stratified epithelia by establishing a reservoir
of low-level infection in the dividing basal cells and restricting the production of viral particles …

Tumorigenesis due to viral infection accounts for a high fraction of the total global cancer
burden (15–20%) of all human cancers. A comprehensive understanding of the mechanisms …