Integrator is a metazoan-specific protein complex capable of inducing termination at all
RNAPII-transcribed loci. Integrator recognizes paused, promoter-proximal RNAPII and …

In higher eukaryotes, fine-tuned activation of protein-coding genes and many non-coding
RNAs pivots around the regulated activity of RNA polymerase II (Pol II). The Integrator …

The worldwide decline in amphibians has been attributed to several causes, especially
habitat loss and disease. We identified a further factor, namely “habitat split”—defined as …

The C-terminal domain (CTD) of RNA polymerase II (RNAPII) is an essential component of
transcriptional regulation and RNA processing of protein-coding genes. A large body of data …

The pervasiveness of RNA synthesis in eukaryotes is largely the result of RNA polymerase II
(Pol II)-mediated transcription, and termination of its activity is necessary to partition the …

Most eukaryotic messenger RNA precursors (pre-mRNAs) undergo extensive maturational
processing, including cleavage and polyadenylation at the 3′-end,,,,,,,. Despite the …

Gene transcription in the cell nucleus is a complex and highly regulated process.
Transcription in eukaryotes requires three distinct RNA polymerases, each of which employs …

Most eukaryotic mRNA precursors (premRNAs) must undergo extensive processing,
including cleavage and polyadenylation at the 3′-end. Processing at the 3′-end is …

The concept of early termination as an important means of transcriptional control has long
been established. Even so, its role in metazoan gene expression is underappreciated …

Cleavage and polyadenylation specificity factor (CPSF) is the central component of the 3′
processing machinery for polyadenylated mRNAs in metazoans: CPSF recognizes the …