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The aetiology and molecular landscape of insulin resistance
Insulin resistance, defined as a defect in insulin-mediated control of glucose metabolism in
tissues—prominently in muscle, fat and liver—is one of the earliest manifestations of a …
tissues—prominently in muscle, fat and liver—is one of the earliest manifestations of a …
Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance
RCR Meex, MJ Watt - Nature Reviews Endocrinology, 2017 - nature.com
Hepatic steatosis is an underlying feature of nonalcoholic fatty liver disease (NAFLD), which
is the most common form of liver disease and is present in up to∼ 70% of individuals who …
is the most common form of liver disease and is present in up to∼ 70% of individuals who …
The role of oxidative stress and hypoxia in pancreatic beta-cell dysfunction in diabetes mellitus
Significance: Metabolic syndrome is a frequent precursor of type 2 diabetes mellitus (T2D), a
disease that currently affects∼ 8% of the adult population worldwide. Pancreatic beta-cell …
disease that currently affects∼ 8% of the adult population worldwide. Pancreatic beta-cell …
Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training
CK Roberts, AL Hevener… - Comprehensive …, 2013 - pmc.ncbi.nlm.nih.gov
Metabolic syndrome (MS) is a collection of cardiometabolic risk factors that includes obesity,
insulin resistance, hypertension, and dyslipidemia. Although there has been significant …
insulin resistance, hypertension, and dyslipidemia. Although there has been significant …
Mechanisms of glucocorticoid-induced insulin resistance: focus on adipose tissue function and lipid metabolism
EB Geer, J Islam, C Buettner - Endocrinology and Metabolism …, 2014 - endo.theclinics.com
Mechanisms of Glucocorticoid-Induced Insulin Resistance - Endocrinology and Metabolism
Clinics Skip to Main Content Skip to Main Menu Advertisement Endocrinology and Metabolism …
Clinics Skip to Main Content Skip to Main Menu Advertisement Endocrinology and Metabolism …
Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes
In both type 1 and type 2 diabetes, the late diabetic complications in nerve, vascular
endothelium, and kidney arise from chronic elevations of glucose and possibly other …
endothelium, and kidney arise from chronic elevations of glucose and possibly other …
Interorgan metabolic crosstalk in human insulin resistance
Excessive energy intake and reduced energy expenditure drive the development of insulin
resistance and metabolic diseases such as obesity and type 2 diabetes mellitus. Metabolic …
resistance and metabolic diseases such as obesity and type 2 diabetes mellitus. Metabolic …
Fat-suppression techniques for 3-T MR imaging of the musculoskeletal system
Fat suppression is an important technique in musculoskeletal imaging to improve the
visibility of bone-marrow lesions; evaluate fat in soft-tissue masses; optimize the contrast-to …
visibility of bone-marrow lesions; evaluate fat in soft-tissue masses; optimize the contrast-to …
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
Type 2 diabetes mellitus (DM) is characterized by insulin resistance and pancreatic β cell
dysfunction. In high-risk subjects, the earliest detectable abnormality is insulin resistance in …
dysfunction. In high-risk subjects, the earliest detectable abnormality is insulin resistance in …
Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes
JD McGarry - Diabetes, 2002 - diabetesjournals.org
Readers of this journal do not need to be re-minded of the explosive increase in obesity/type
2 diabetes syndromes and their attendant staggering public health costs that are currently …
2 diabetes syndromes and their attendant staggering public health costs that are currently …