The current conceptualization of Alzheimer disease (AD) is driven by the amyloid
hypothesis, in which a deterministic chain of events leads from amyloid deposition and then …

Ageing is the primary risk factor for most neurodegenerative diseases, including Alzheimer
disease (AD) and Parkinson disease (PD). One in ten individuals aged≥ 65 years has AD …

APOE4 is the strongest genetic risk factor for Alzheimer's disease,–. However, the effects of
APOE4 on the human brain are not fully understood, limiting opportunities to develop …

Ageing is an inevitable event in the lifecycle of all organisms, characterized by progressive
physiological deterioration and increased vulnerability to death. Ageing has also been …

Modifiable risk and protective factors for boosting brain and cognitive development and
preventing neurodegeneration and cognitive decline are embraced in neuroimaging …

In humans, the period from term birth to∼ 2 years of age is characterized by rapid and
dynamic brain development and plays an important role in cognitive development and risk of …

Throughout infancy, childhood, and adolescence, our brains undergo remarkable changes.
Processes including myelination and synaptogenesis occur rapidly across the first 2–3 years …

A major feature of Alzheimer's disease (AD) pathology is the plaque composed of
aggregated amyloid-β (Aβ) peptide. Although these plaques may have harmful properties …

Globally, 50 million people live with dementia, with Alzheimer disease (AD) being
responsible for two-thirds of the total cases. As ageing is the main risk factor for dementia …

Age, apolipoprotein E ε4 (APOE) and chromosomal sex are well-established risk factors for
late-onset Alzheimer's disease (LOAD; AD). Over 60% of persons with AD harbor at least …