Therapeutic potentials of microalgae and their bioactive compounds on diabetes mellitus
Diabetes mellitus is a metabolic disorder characterized by hyperglycemia due to impaired
insulin secretion, insulin resistance, or both. Oxidative stress and chronic low-grade …
insulin secretion, insulin resistance, or both. Oxidative stress and chronic low-grade …
[HTML][HTML] DPP-IV Inhibitory Peptide against In Vitro Gastrointestinal Digestion Derived from Goat's Milk Protein and Its Activity Enhancement via Amino Acid Substitution
B He, Y Lian, H Xue, Y Zhou, Y Wei, J Ma, Y Tan… - Foods, 2024 - pmc.ncbi.nlm.nih.gov
Goat milk protein can release a variety of bioactive peptides after digestion, while most of
them are digested into free amino acids or dipeptides via the GI tract. We investigated the …
them are digested into free amino acids or dipeptides via the GI tract. We investigated the …
A Captivating Potential of Schiff Bases Derivatives for Antidiabetic Activity
R Sahu, K Shah - Current Pharmaceutical Design, 2025 - benthamdirect.com
A double bond between the nitrogen and carbon atoms characterizes a wide class of
compounds known as Schiff bases. The flexibility of Schiff bases is formed from several …
compounds known as Schiff bases. The flexibility of Schiff bases is formed from several …
[HTML][HTML] Angular-Substituted [1, 4] Thiazino [3, 4-a] Isoquinolines: Biological Evaluation and In Silico Studies on DPP-IV Inhibition
Recent studies have discovered that aryl-substituted pyrido [2, 1-a] isoquinolines have the
potential to be highly active DPP IV inhibitors. In previous studies, we reported a novel …
potential to be highly active DPP IV inhibitors. In previous studies, we reported a novel …
Bis (benzimidazol‐2‐yl) amine‐Based DPP‐4 Inhibitors Potentially Suitable for Combating Diabetes and Associated Nervous System Alterations
K Tomović Pavlović, BS Ilić, L Leitzbach… - Chemistry & …, 2024 - Wiley Online Library
Abstract Bis (benzimidazol‐2‐yl) amine scaffold is not present in dipeptidyl peptidase‐4
(DPP‐4) inhibitors published so far. Herein, the inhibitory potential of bis (benzimidazol‐2 …
(DPP‐4) inhibitors published so far. Herein, the inhibitory potential of bis (benzimidazol‐2 …
[HTML][HTML] Design and synthesis of new coumarin-1, 2, 3-triazole hybrids as new antidiabetic agents: In vitro α-amylase, α-glucosidase inhibition, anti-inflammatory, and …
VC Barangi, LA Shastri, PK Chowdegowda… - European Journal of …, 2024 - eurjchem.com
The current study focuses on the synthesis of coumarin-triazole hybrids (7i-t) starting from 4-
hydroxy benzaldehyde or 4-hydroxyacetophenone (1a-b) and propargyl bromide. On the …
hydroxy benzaldehyde or 4-hydroxyacetophenone (1a-b) and propargyl bromide. On the …
Hit Selection of Dipeptidyl Peptidase‐4 Inhibitors Bearing Thieno [2, 3‐d] pyrimidine Scaffold
K Tomović Pavlović, BS Ilić, S Dimov… - Chemistry & …, 2024 - Wiley Online Library
The thieno [2, 3‐d] pyrimidine fragment is in the structure of many drug‐like candidate
derivatives with a wide range of biological activities. However, very few dipeptidyl peptidase …
derivatives with a wide range of biological activities. However, very few dipeptidyl peptidase …
Identification of small-molecule glucokinase activator for type-2-diabetes treatment: a structure-based virtual screening approach
ABSTRACT Glucokinase (GK, EC 2.7. 1.2) is a crucial enzyme that catalyses the conversion
of glucose to glucose-6-phosphate. It is used to treat type-2 diabetes (T2D), a serious …
of glucose to glucose-6-phosphate. It is used to treat type-2 diabetes (T2D), a serious …
Assessment of the Efficiency of Selecting Promising Compounds During Virtual Screening Based on Various Estimations of Drug-Likeness
VS Sukhachev, AV Dmitriev, SM Ivanov… - Pharmaceutical …, 2025 - Springer
Progress in synthetic and medicinal chemistry significantly expands the chemical space
where new pharmacological substances are discovered. Virtual screening is a preliminary …
where new pharmacological substances are discovered. Virtual screening is a preliminary …
Predictive bioactivity of compounds from Vitis gracilis leaf extract to counteract doxorubicin-induced cardiotoxicity via sirtuin 1 and adenosine monophosphate …
Doxorubicin is a potent chemotherapy drug. However, it is known to cause cardiotoxicity via
inhibition of sirtuin 1 (SIRT1) and adenosine monophosphate protein kinase (AMPK) activity …
inhibition of sirtuin 1 (SIRT1) and adenosine monophosphate protein kinase (AMPK) activity …