Histone modifications are key epigenetic regulatory features that have important roles in
many cellular events. Lysine methylations mark various sites on the tail and globular …

Protein lysine methylation is a crucial post-translational modification that regulates the
functions of both histone and non-histone proteins. Deregulation of the enzymes or 'writers' …

Methylation of histone H3 K79 by Dot1L is a hallmark of actively transcribed genes that
depends on monoubiquitination of H2B K120 (H2B-Ub) and is an example of histone …

Protein semisynthesis—defined herein as the assembly of a protein from a combination of
synthetic and recombinant fragments—is a burgeoning field of chemical biology that has …

Polycomb group (PcG) proteins are transcriptional repressors that control processes ranging
from the maintenance of cell fate decisions and stem cell pluripotency in animals to the …

Protein lysine methylation is a distinct posttranslational modification that causes minimal
changes in the size and electrostatic status of lysine residues. Lysine methylation plays …

DNA double strand breaks need to be repaired in an organized fashion to preserve genomic
integrity. In the organization of faithful repair, histone ubiquitination plays a crucial role …

Regulation of chromatin structure involves histone posttranslational modifications that can
modulate intrinsic properties of the chromatin fiber to change the chromatin state. We used …

Designer amino acids, beyond the canonical 20 that are normally used by cells, can now be
site-specifically encoded into proteins in cells and organisms. This is achieved …

ATP-dependent chromatin remodellers regulate access to genetic information by controlling
nucleosome positions in vivo. However, the mechanism by which remodellers discriminate …