Interleukin-15 as a myokine: mechanistic insight into its effect on skeletal muscle metabolism

L Nadeau, C Aguer - Applied Physiology, Nutrition, and …, 2019 - cdnsciencepub.com
Interleukin (IL)-15 is a cytokine with important immunological functions. It is highly expressed
in skeletal muscle and is believed to be a myokine, a hypothesis supported by the rapid …

Mitochondria homeostasis and oxidant/antioxidant balance in skeletal muscle—do myokines play a role?

BPS Pang, WS Chan, CB Chan - Antioxidants, 2021 - mdpi.com
Mitochondria are the cellular powerhouses that generate adenosine triphosphate (ATP) to
substantiate various biochemical activities. Instead of being a static intracellular structure …

Skeletal muscle IL‐15/IL‐15Rα and myofibrillar protein synthesis after resistance exercise

A Pérez‐López, J McKendry… - … journal of medicine …, 2018 - Wiley Online Library
In vitro and in vivo studies described the myokine IL‐15 and its receptor IL‐15Rα as
anabolic/anti‐atrophy agents, however, the protein expression of IL‐15Rα has not been …

Skeletal muscle reprogramming by breast cancer regardless of treatment history or tumor molecular subtype

HE Wilson, DA Stanton, C Montgomery, AM Infante… - NPJ Breast …, 2020 - nature.com
Increased susceptibility to fatigue is a negative predictor of survival commonly experienced
by women with breast cancer (BC). Here, we sought to identify molecular changes induced …

[HTML][HTML] Preclinical Multi-Omic Assessment of Pioglitazone in Skeletal Muscles of Mice Implanted with Human HER2/neu Overexpressing Breast Cancer Xenografts

SA Clayton, AD Mizener, MA Whetsell, LE Rentz… - Cancers, 2024 - mdpi.com
Abstract Background/Objectives: Breast cancer (BC) is the second most commonly
diagnosed cancer worldwide and is accompanied by fatigue during both active disease and …

Hippocampus-specific deficiency of IL-15Rα contributes to greater anxiety-like behaviors in mice

L Nguyen, J Bohlen, J Stricker, I Chahal, H Zhang… - Metabolic brain …, 2017 - Springer
Abstract A hippocampus-specific IL15RαKO mouse (hipIl15ra fl/fl/Cre+) was generated to
test the hypothesis that the targeted deletion of interleukin-15 receptor alpha (IL-15Rα) in the …

Mitochondrial ultrastructural adaptations in fast muscles of mice lacking IL15RA

E Loro, S Bisetto, TS Khurana - Journal of Cell Science, 2018 - journals.biologists.com
The pro-inflammatory cytokine interleukin-15 (IL15) and its receptor α (IL15RA) participate in
the regulation of musculoskeletal function and metabolism. Deletion of the Il15ra gene in …

Effect of Interleukin-15 Receptor Alpha Ablation on the Metabolic Responses to Moderate Exercise Simulated by in vivo Isometric Muscle Contractions

E Loro, C Jang, WJ Quinn III, JA Baur, ZP Arany… - Frontiers in …, 2019 - frontiersin.org
Lack of interleukin 15 receptor alpha (IL15RA) increases spontaneous activity, exercise
capacity and protects from diet-induced obesity by enhancing muscle energy metabolism …

What if? Mouse proteomics after gene inactivation

E Gianazza, I Miller, U Guerrini, L Palazzolo… - Journal of …, 2019 - Elsevier
The complex interactions among proteins and of proteins with small molecular weight
protein ligands are overturned every time one of the components of the network is missing …

[PDF][PDF] Mitochondria Homeostasis and Oxidant/Antioxidant Balance in Skeletal Muscle—Do Myokines Play a Role? Antioxidants 2021, 10, 179

BPS Pang, WS Chan, CB Chan - 2021 - pdfs.semanticscholar.org
Mitochondria are the cellular powerhouses that generate adenosine triphosphate (ATP) to
substantiate various biochemical activities. Instead of being a static intracellular structure …