Understanding functional effects of genetic variants is one of the key challenges in human
genetics, as much of disease-associated variation is located in non-coding regions with …

Advances in transcriptome sequencing allow for simultaneous interrogation of differentially
expressed genes from multiple species originating from a single RNA sample, termed dual …

White adipose tissue, once regarded as morphologically and functionally bland, is now
recognized to be dynamic, plastic and heterogenous, and is involved in a wide array of …

We present STARsolo, a comprehensive turnkey solution for quantifying gene expression in
single-cell/nucleus RNA-seq data, built into RNA-seq aligner STAR. Using simulated data …

There is currently little information about the evolution of gene clusters, genome
architectures and karyotypes in early branching animals. Slowly evolving anthozoan …

Here we walk through an end-to-end gene-level RNA-Seq differential expression workflow
using Bioconductor packages. We will start from the FASTQ files, show how these were …

MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene
regulation that have a major impact on many diseases and provide an exciting avenue …

Background Capturing the genetic diversity of wild relatives is crucial for improving crops
because wild species are valuable sources of agronomic traits that are essential to enhance …

Background Termites primarily feed on lignocellulose or soil in association with specific gut
microbes. The functioning of the termite gut microbiota is partly understood in a handful of …

Aligning sequencing reads onto a reference is an essential step of the majority of genomic
analysis pipelines. Computational algorithms for read alignment have evolved in …