Biomolecule-assisted green synthesis of nanostructured calcium phosphates and their biomedical applications
Calcium phosphates (CaPs) are ubiquitous in nature and vertebrate bones and teeth, and
have high biocompatibility and promising applications in various biomedical fields …
have high biocompatibility and promising applications in various biomedical fields …
Immunometabolism in early and late stages of rheumatoid arthritis
One of the fundamental traits of immune cells in rheumatoid arthritis (RA) is their ability to
proliferate, a property shared with the joint-resident cells that form the synovial pannus. The …
proliferate, a property shared with the joint-resident cells that form the synovial pannus. The …
Metabolites released from apoptotic cells act as tissue messengers
Caspase-dependent apoptosis accounts for approximately 90% of homeostatic cell turnover
in the body, and regulates inflammation, cell proliferation, and tissue regeneration,–. How …
in the body, and regulates inflammation, cell proliferation, and tissue regeneration,–. How …
Sepsis expands a CD39+ plasmablast population that promotes immunosuppression via adenosine-mediated inhibition of macrophage antimicrobial activity
Sepsis results in elevated adenosine in circulation. Extracellular adenosine triggers
immunosuppressive signaling via the A2a receptor (A2aR). Sepsis survivors develop …
immunosuppressive signaling via the A2a receptor (A2aR). Sepsis survivors develop …
Cellular metabolic adaptations in rheumatoid arthritis and their therapeutic implications
Activation of endothelium and immune cells is fundamental to the initiation of autoimmune
diseases such as rheumatoid arthritis (RA), and it results in trans-endothelial cell migration …
diseases such as rheumatoid arthritis (RA), and it results in trans-endothelial cell migration …
The purinergic system as a pharmacological target for the treatment of immune-mediated inflammatory diseases
Immune-mediated inflammatory diseases (IMIDs) encompass a wide range of seemingly
unrelated conditions, such as multiple sclerosis, rheumatoid arthritis, psoriasis, inflammatory …
unrelated conditions, such as multiple sclerosis, rheumatoid arthritis, psoriasis, inflammatory …
Inhibition of glycolysis reduces disease severity in an autoimmune model of rheumatoid arthritis
G Abboud, SC Choi, N Kanda… - Frontiers in …, 2018 - frontiersin.org
The K/BxN mouse is a spontaneous model of arthritis driven by T cell receptor transgenic
CD4+ T cells from the KRN strain that are activated by glucose-6-phosphate isomerase …
CD4+ T cells from the KRN strain that are activated by glucose-6-phosphate isomerase …
First we eat, then we do everything else: The dynamic metabolic regulation of efferocytosis
Clearance of apoptotic cells, or" efferocytosis," is essential for diverse processes including
embryonic development, tissue turnover, organ regeneration, and immune cell …
embryonic development, tissue turnover, organ regeneration, and immune cell …
Fibroblast-like synoviocytes glucose metabolism as a therapeutic target in rheumatoid arthritis
Metabolomic studies show that rheumatoid arthritis (RA) is associated with metabolic
disruption that may be therapeutically targetable. Among them, glucose metabolism and …
disruption that may be therapeutically targetable. Among them, glucose metabolism and …
Fructose-1,6-bisphosphate prevents pregnancy loss by inducing decidual COX-2+ macrophage differentiation
WJ Zhou, HL Yang, J Mei, KK Chang, H Lu, ZZ Lai… - Science …, 2022 - science.org
Decidualization is an intricate biological process in which extensive remodeling of the
endometrium occurs to support the development of an implanting blastocyst. However, the …
endometrium occurs to support the development of an implanting blastocyst. However, the …