The application of physiologically-based pharmacokinetic (PBPK) modeling is coming of
age in drug development and regulation, reflecting significant advances over the past 10 …

The activated serine protease factor Xa is a promising target for new anticoagulants. After
studies on naturally occurring factor Xa inhibitors indicated that such agents could be …

Drug metabolism and pharmacokinetics (DMPK) is an important branch of pharmaceutical
sciences. The nature of ADME (absorption, distribution, metabolism, excretion) and PK …

Introduction: Since their initial discovery in 1989, grapefruit juice (GFJ)–drug interactions
have received extensive interest from the scientific, medical, regulatory and lay communities …

Analytical monitoring surveys routinely confirm that organisms in the environment are
exposed to complex multi-component pharmaceutical mixtures. We are hence tasked with …

We studied the time course for the reversal of rifampin's effect on the pharmacokinetics of
oral midazolam (a cytochrome P450 (CYP) 3A4 substrate) and digoxin (a P‐glycoprotein (P …

A recent paper in this journal sought to counter evidence for the role of transport proteins in
effecting drug uptake into cells, and questions that transporters can recognize drug …

Current surgical safety guidelines and checklists are generic and are not specifically tailored
to address patient issues and risk factors in surgical subspecialties. Patient safety in surgical …

Many intrinsic and extrinsic factors can affect an individual patient's drug exposure and
response. 1 The US Food and Drug Administration (FDA) has published a number of …

The human CYP2A gene subfamily consists of three members, CYP2A6, CYP2A7, and
CYP2A13. The CYP2A6 gene is highly polymorphic with approximately 40 annotated allelic …