Myelin water fraction (MWF) imaging has emerged as a promising magnetic resonance
imaging (MRI) biomarker for investigating brain function and composition. This …

Quantitative MRI modalities, such as diffusion tensor imaging (DTI) or magnetization transfer
imaging (MTI) are sensitive to the neuronal effects of aging of the cerebral white matter …

Purpose To develop an efficient algorithm for multi‐component analysis of magnetic
resonance fingerprinting (MRF) data without making a priori assumptions about the exact …

Multi-component T 2 relaxometry allows probing tissue microstructure by assessing
compartment-specific T 2 relaxation times and water fractions, including the myelin water …

Non-invasive quantification of the in vivo myelin content may provide valuable information
regarding healthy maturation of the brain, as well as insights into demyelination of several …

Purpose Although several MRI methods have been explored to achieve in vivo myelin
quantification, imaging the whole brain in clinically acceptable times and sufficiently high …

Previous in-vivo magnetic resonance imaging (MRI)-based studies of age-related
differences in the human brainstem have focused on volumetric morphometry. These …

Multi-echo T 2 magnetic resonance images contain information about the distribution of T 2
relaxation times of compartmentalized water, from which we can estimate relevant brain …

Purpose We present a computationally feasible and iterative multi-voxel spatially
regularized algorithm for myelin water fraction (MWF) reconstruction. This method utilizes 3D …

Demyelination is the key pathological process in multiple sclerosis (MS). The extent of
demyelination can be quantified with magnetic resonance imaging by assessing the myelin …