A diverse array of sex determination (SD) mechanisms, encompassing environmental to
genetic, have been found to exist among vertebrates, covering a spectrum from fixed SD …

Thyroid hormones (THs) are well-known regulators of development and metabolism in
vertebrates. There is increasing evidence that THs are also involved in gonadal …

It is well accepted that Forkhead box protein L2 (Foxl2) and aromatase (Cyp19a1; the
enzyme responsible for estrogen synthesis) are critical for ovarian development in …

Foxl2 is a member of the large family of Forkhead Box (Fox) domain transcription factors. It
emerged during the last 15 years as a key player in ovarian differentiation and oogenesis in …

Concern over global amphibian declines and possible links to agrochemical use has led to
research on the endocrine disrupting actions of agrochemicals, such as fertilizers …

Amphibians have been widely used to study developmental biology due to the fact that
embryo development takes place independently of the maternal organism and that …

How to conserve our planet's rapidly disappearing biodiversity is one of the greatest
challenges of our generation. Among terrestrial vertebrate taxa, amphibians are most at risk …

All amphibian species are known to have genetic sex determination. However, a variety of
environmental conditions can moderate sexual differentiation, in some cases leading to sex …

Amphibians are threatened on a global scale and pollutants may be contributing to
population declines, but how chemicals impact on their reproduction is poorly understood …

Abstract Development of the gonads is a complex process, which starts with a period of
undifferentiated, bipotential gonads. During this period the expression of sex-determining …