Neurons are terminally differentiated cells that use their microtubule arrays not for cell
division but rather as architectural elements required for the elaboration of elongated axons …

Nerve cells establish their connections by extending neuritic processes away from the rather
fixed position of the cell body. In the case of axons, this growth can be extensive and the …

The polarity of neurons, which is integral to their function, is a result of the segregated
distribution of molecules and organelles. The polarized distribution of cytoskeletal proteins …

Tau protein undergoes a shift in its molecular mass and its electrophoretic complexity during
early postnatal development. We have sequenced a tau cDNA from an adult rat brain …

Abstract INSULIN-DEPENDENT diabetes mellitus (IDDM) in non-obese diabetic (NOD) mice
results from the T-lymphocyte-mediated destruction of the insulin-producing pancreatic β …

We sought to determine whether the strict segregation of MAP2 and tau into somatodendritic
and axonal compartments in situ was maintained in dissociated neuronal cultures of the rat …

In a previous study, F-actin appeared to play a key role in guiding microtubules during
growth cone-target interactions. Here, F-actin flow patterns were assessed to investigate the …

Using the technique of homologous recombination in embryonic stem cells, we generated
mice bearing a targeted disruption of the gene encoding the neurofilament light (NF-L) …

Migrating cells display a characteristic polarization of the actin cytoskeleton. Actin filaments
polymerise in the protruding front of the cell whereas actin filament bundles contract in the …

Microtubule-associated protein tau is localized to the axon in situ and has been implicated in
the development of neuronal polarity. Here we report that tau is extracted differentially in …