The serious drawbacks of the conventional treatment of pancreatic ductal adenocarcinoma
(PDAC) such as nonspecific toxicity and high resistance to chemo and radiation therapy …

Abstract Abstract Background, Breast cancer (BC) is one of the leading causes of cancer
related deaths in Iran. This high ratio of mortality had a rising trend during the recent years …

The aim of this study was to investigate the influence of the Notch1 activity level on the
pharmacological interaction between cisplatin (CDDP) and two histone deacetylase …

Background: Autosomal-dominant polycystic kidney disease (ADPKD) is the most prevalent
inherited genetic disease of cats, predominantly affecting Persians and Persian-related cats …

Background We identified increased β-catenin and Atk expression was associated with drug
resistance and poor prognosis in breast cancer patients using public databases. Antrocin …

Notch1 signaling pathway is an evolutionarily conserved and crucial regulator to determine
cell fate and differentiation. Notch1 is often over expressed in several cancers, which plays …

Background The aim of this study was to investigate the correlations between ADAMTSs
expression and breast invasive ductal carcinoma (IDC), and to offer a theoretical basis for …

The interrelation of cancer and Alzheimer's disorder (AD)-associated molecular
mechanisms, reported last decade, paved the path for drug discoveries. In this direction …

Purpose: The study investigates the therapeutic effect of Oridonin on PTEN loss and HER2
amplification PI3K/AKT signaling hyper-activated (p-AKTHigh) breast cancer. Methods: The …